EA-3167

EA-3167
(IUPAC) ime
1-azabiciklo[2.2.2]oktan-8-il 2-ciklopentil-2-hidroksi-2-feniletanoat
Klinički podaci
Identifikatori
CAS broj 26758-53-2
ATC kod ?
PubChem[1][2] 33597
Hemijski podaci
Formula C20H29NO3 
Mol. masa 329,433 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

EA-3167 je potentan i dugotrajan antiholinergijski delirijantni lek. On je srodan sa hemijskim bojnim agensom 3-hinuklidinil benzilatom (QNB). EA-3167 je razvijen u okviru jednog vojnog kontrakta tokom 1960-tih kao deo programa za hemijsko oružje SAD-a. Cilj je bio da se razvije neletalno onesposobljavajuće sredstvo. EA-3167 je imao identično dejstvo kao i QNB, ali je bio potentniji i dugotrajniji, sa efektivnom dozom pri primeni putem injekcije od 2,5 μg/kg (i.e. 0,2 miligrama za osobu sa 80 kg), i trajanjem od 120-240 sati (5-10 dana).[3][4] Međutim za razliku od QNB-a, EA-3167 nije bio razvijen u oružje, niti proizvođen u velikim količinama.

Reference

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents, Volume 1 (1982). Commission on Life Sciences. The National Academies Press. pp195-196.
  4. Ketchum JS. Chemical Warfare Secrets Almost Forgotton. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc 2006. ISBN 978-1-4243-0080-8

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