Salvinorina A

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Salvinorina A
Struttura della molecola
Struttura della molecola
Nome IUPAC
metil-(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetilossi)-2-(furan-3-il)-6a,

10b-dimetil-4,10-diossododecaidro-2H-benzo[f]isocromene-7-carbossilato

Caratteristiche generali
Formula bruta o molecolareC23H28O8
Massa molecolare (u)432,46
Numero CAS83729-01-5
Numero EINECS689-027-2
PubChem128563 CID 128563
DrugBankDBDB12327
SMILES
CC(=O)OC1CC(C2(CCC3C(=O)OC(CC3(C2C1=O)C)C4=COC=C4)C)C(=O)OC
Indicazioni di sicurezza
Modifica dati su Wikidata · Manuale

La salvinorina A è un allucinogeno dissociativo e psichedelico. In natura si trova esclusivamente nella Salvia divinorum, insieme a molti altri composti chimicamente analoghi. Solubile in solventi organici come etanolo o acetone, meno nell'acqua.

Chimica

Chimicamente la molecola è un diterpenoide neoclerodano. Non contiene nessun atomo di azoto, quindi non è un alcaloide, contrariamente a tutti gli altri psichedelici naturali (bufotenina, mescalina, psilocibina ecc.) e a molti psichedelici semi-sintetici (LSD). È possibile sintetizzarla ma è meno dispendioso estrarla dalla pianta.

Farmacodinamica

La salvinorina A è un agonista dei recettori κ-oppioidi e recentemente si è scoperta una sua moderata affinità per alcuni sottotipi di recettori della dopamina, diversamente dagli altri psichedelici, la cui azione è mediata soprattutto dalle loro proprietà agoniste nei confronti dei recettori 5-HT2A della serotonina. Psicoattiva a dosi di appena 200µg, è il più potente allucinogeno naturale conosciuto.

Non manifesta una particolare tossicità neanche a dosi elevate ma il rischio di un'esperienza di profondi terrore e disforia è presente ad ogni assunzione. Queste crisi, in gergo bad trip, sono quasi sempre temporanee. Se l'individuo presentava già patologie psichiche latenti, si corre il rischio di una slatentizzazione.

Stato legale

Note

  1. ^ a b The Legal Status of Salvia divinorum
  2. ^ BOE 032 de 06/02/2004 Sec 1 Pag 5061 a. 5065
  3. ^ Testo della Gazzetta Ufficiale
  4. ^ Erowid Salvia Divinorum Vault : Legal Status

Voci correlate

Altri progetti

Collegamenti esterni

https://www.erowid.org/plants/salvia/salvia.shtml

  Portale Chimica

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