P2RY10

P2RY10
Identifiers
Aliases	P2RY10, LYPSR2, P2Y10, purinergic receptor P2Y10, P2Y receptor family member 10
External IDs	OMIM: 300529; MGI: 1926076; HomoloGene: 8717; GeneCards: P2RY10; OMA:P2RY10 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 78,945,332 bp[1] End 78,963,727 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 106,132,098 bp[2] End 106,148,580 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node epithelium of nasopharynx blood granulocyte appendix spleen epithelium of colon bone marrow superficial temporal artery bone marrow cells Top expressed in mesenteric lymph nodes thymus spleen blood lumbar spinal ganglion subcutaneous adipose tissue white adipose tissue pharynx bone marrow mammary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27334 78826 Ensembl ENSG00000078589 ENSMUSG00000050921 UniProt O00398 Q8BFU7 RefSeq (mRNA) NM_014499 NM_198333 NM_001324218 NM_001324221 NM_001324225 NM_172435 NM_001357810 RefSeq (protein) NP_001311147 NP_001311150 NP_001311154 NP_055314 NP_938147 NP_766023 NP_001344739 Location (UCSC) Chr X: 78.95 – 78.96 Mb Chr X: 106.13 – 106.15 Mb PubMed search [3] [4]
Wikidata
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Putative P2Y purinoceptor 10 is a protein that, in humans, is encoded by the P2RY10 gene.^[5][6][7]

Function

The protein encoded by this gene belongs to the family of G-protein coupled receptors that is preferentially activated by adenosine and uridine nucleotides. Two alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.^[7]

See also

• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000078589 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050921 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (June 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
6. Ralevic V, Burnstock G (September 1998). "Receptors for purines and pyrimidines". Pharmacological Reviews. 50 (3): 413–92. PMID 9755289.
7. "Entrez Gene: P2RY10 purinergic receptor P2Y, G-protein coupled, 10".

Further reading

• Berchtold S, Ogilvie AL, Bogdan C, Mühl-Zürbes P, Ogilvie A, Schuler G, Steinkasserer A (September 1999). "Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases". FEBS Letters. 458 (3): 424–8. doi:10.1016/S0014-5793(99)01197-7. PMID 10570953. S2CID 35306561.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.