Melanin-concentrating hormone receptor

"MCHR" redirects here. For the defunct healthcare advocacy group, see Medical Committee for Human Rights.

melanin-concentrating hormone receptor 1
Identifiers
Symbol	MCHR1
Alt. symbols	GPR24
NCBI gene	2847
HGNC	4479
OMIM	601751
RefSeq	NM_005297
UniProt	Q99705
Other data
Locus	Chr. 22 q13.3
Search for Structures Swiss-model Domains InterPro

melanin-concentrating hormone receptor 2
Identifiers
Symbol	MCHR2
Alt. symbols	GPR145
NCBI gene	84539
HGNC	20867
OMIM	606111
RefSeq	NM_032503
UniProt	Q969V1
Other data
Locus	Chr. 6 q16
Search for Structures Swiss-model Domains InterPro

Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.

• MCH-R1 is expressed in all mammals.
• MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.

Clinical significance

Antagonists might be useful in the treatment of obesity^[1][2] and anxiety and depression.^[3] An agonist might have possible utility as a treatment for osteoporosis^[4] and insomnia^[5]

Research is ongoing for antagonists affecting MCH receptors R1 and R2.^[6][7]

See also

• Melanin concentrating hormone
• Melanin

References

1. Handlon AL, Zhou H (2006). "Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity". J. Med. Chem. 49 (14): 4017–22. doi:10.1021/jm058239j. PMID 16821761.
2. Luthin DR (2007). "Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists". Life Sci. 81 (6): 423–40. doi:10.1016/j.lfs.2007.05.029. PMID 17655875.
3. Shimazaki T, Yoshimizu T, Chaki S (2006). "Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders". CNS Drugs. 20 (10): 801–11. doi:10.2165/00023210-200620100-00002. PMID 16999451. S2CID 32524553.
4. Bohlooly-Y M, Mahlapuu M, Andersén H, Astrand A, Hjorth S, Svensson L, Törnell J, Snaith MR, Morgan DG, Ohlsson C (2004). "Osteoporosis in MCHR1-deficient mice". Biochem. Biophys. Res. Commun. 318 (4): 964–9. doi:10.1016/j.bbrc.2004.04.122. PMID 15147966.
5. Monti JM, Torterolo P, Lagos P (August 2013). "Melanin-concentrating hormone control of sleep-wake behavior". Sleep Med Rev. 17 (4): 293–8. doi:10.1016/j.smrv.2012.10.002. PMID 23477948.
6. Saito Y, Maruyama K (2006). "Identification of melanin-concentrating hormone receptor and its impact on drug discovery". Journal of Experimental Zoology Part A: Comparative Experimental Biology. 305 (9): 761–8. Bibcode:2006JEZA..305..761S. doi:10.1002/jez.a.311. PMID 16902961.
7. McBriar MD (2006). "Recent advances in the discovery of melanin-concentrating hormone receptor antagonists". Current Opinion in Drug Discovery & Development. 9 (4): 496–508. PMID 16889232.

External links

• "Melanin-Concentrating Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
• melanin-concentrating+hormone+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• MCHR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• MCHR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)