Platelet-activating factor receptor

PTAFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B0X
Identifiers
Aliases	PTAFR, PAFR, platelet activating factor receptor
External IDs	OMIM: 173393; MGI: 106066; HomoloGene: 20260; GeneCards: PTAFR; OMA:PTAFR - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,147,166 bp[1] End 28,193,936 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.3|4 65.56 cM Start 132,291,378 bp[2] End 132,309,994 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte bone marrow vena cava nasal epithelium pericardium cecum body of tongue bone marrow cells Top expressed in granulocyte bone marrow white adipose tissue jejunum esophagus ileum spleen zone of skin urinary bladder muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity G protein-coupled purinergic nucleotide receptor activity lipopolysaccharide binding signal transducer activity mitogen-activated protein kinase binding platelet activating factor receptor activity phospholipid binding lipopolysaccharide immune receptor activity protein binding Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane secretory granule membrane tertiary granule membrane Biological process G protein-coupled receptor signaling pathway positive regulation of leukocyte tethering or rolling inositol trisphosphate biosynthetic process positive regulation of voltage-gated chloride channel activity positive regulation of phospholipase C activity negative regulation of blood pressure interferon-gamma-mediated signaling pathway positive regulation of inositol phosphate biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcytosis cytokine production response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine response to symbiotic bacterium transcytosis positive regulation of translation cellular response to gravity response to dexamethasone positive regulation of cellular extravasation positive regulation of maternal process involved in parturition chemotaxis cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine positive regulation of sensory perception of pain response to lipopolysaccharide cellular response to fatty acid response to organophosphorus birth positive regulation of vasoconstriction immune response positive regulation of gastro-intestinal system smooth muscle contraction positive regulation of tumor necrosis factor production inflammatory response positive regulation of smooth muscle contraction positive regulation of neutrophil degranulation positive regulation of leukocyte cell-cell adhesion phosphatidylinositol-mediated signaling lipopolysaccharide-mediated signaling pathway cellular response to cAMP signal transduction positive regulation of smooth muscle cell proliferation G protein-coupled purinergic nucleotide receptor signaling pathway neutrophil degranulation cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5724 19204 Ensembl ENSG00000169403 ENSMUSG00000056529 UniProt P25105 Q62035 RefSeq (mRNA) NM_001164723 NM_000952 NM_001164721 NM_001164722 NM_001081211 RefSeq (protein) NP_000943 NP_001158193 NP_001158194 NP_001158195 NP_001074680 Location (UCSC) Chr 1: 28.15 – 28.19 Mb Chr 4: 132.29 – 132.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor.^[5][6] It is encoded in the human by the PTAFR gene.

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]^[7] Its pathogenetic role in chronic kidney failure has also been reported recently.^[8]

Ligands

Agonists

• Platelet activating factor

Antagonists

• Apafant (WEB-2086)
• Israpafant (Y-24180)
• Lexipafant
• Rupatadine

References

1. GRCh38: Ensembl release 89: ENSG00000169403 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056529 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics. 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
6. Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68–69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.
7. "Entrez Gene: PTAFR platelet-activating factor receptor".
8. Correa-Costa M (Apr 2014). "Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis". Lab. Invest. 94 (4): 455–466. doi:10.1038/labinvest.2013.155. PMID 24492283.

Further reading

• Shukla SD (1992). "Platelet-activating factor receptor and signal transduction mechanisms". FASEB J. 6 (6): 2296–301. doi:10.1096/fasebj.6.6.1312046. PMID 1312046. S2CID 6000303.
• Sugimoto T, Tsuchimochi H, McGregor CG, et al. (1993). "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart". Biochem. Biophys. Res. Commun. 189 (2): 617–24. doi:10.1016/0006-291X(92)92245-S. PMID 1281995.
• Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics. 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
• Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog". J. Biol. Chem. 267 (13): 9101–6. doi:10.1016/S0021-9258(19)50394-5. PMID 1374385.
• Ye RD, Prossnitz ER, Zou AH, Cochrane CG (1991). "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor". Biochem. Biophys. Res. Commun. 180 (1): 105–11. doi:10.1016/S0006-291X(05)81261-6. PMID 1656963.
• Nakamura M, Honda Z, Izumi T, et al. (1991). "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes". J. Biol. Chem. 266 (30): 20400–5. doi:10.1016/S0021-9258(18)54936-X. PMID 1657923.
• Haslam RJ, Williams KA, Davidson MM (1985). "Receptor-Effector Coupling in Platelets: Roles of Guanine Nucleotides". Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology. Vol. 192. pp. 265–80. doi:10.1007/978-1-4615-9442-0_19. ISBN 978-1-4615-9444-4. PMID 3010668.
• Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine". Immunology. 52 (1): 169–74. PMC 1454573. PMID 6325330.
• Cundell DR, Gerard NP, Gerard C, et al. (1995). "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor". Nature. 377 (6548): 435–8. Bibcode:1995Natur.377..435C. doi:10.1038/377435a0. PMID 7566121. S2CID 4318257.
• Izumi T, Kishimoto S, Takano T, et al. (1995). "Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation". Biochem. J. 305. ( Pt 3) (3): 829–35. doi:10.1042/bj3050829. PMC 1136334. PMID 7848283.
• Bito H, Honda Z, Nakamura M, Shimizu T (1994). "Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA". Eur. J. Biochem. 221 (1): 211–8. doi:10.1111/j.1432-1033.1994.tb18731.x. PMID 8168510.
• Chase PB, Halonen M, Regan JW (1993). "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region". Am. J. Respir. Cell Mol. Biol. 8 (3): 240–4. doi:10.1165/ajrcmb/8.3.240. PMID 8383507.
• Mutoh H, Bito H, Minami M, et al. (1993). "Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor". FEBS Lett. 322 (2): 129–34. doi:10.1016/0014-5793(93)81552-B. PMID 8387031. S2CID 44640249.
• Nakamura M, Honda Z, Matsumoto T, et al. (1993). "Isolation and properties of platelet-activating factor receptor cDNAs". Journal of Lipid Mediators. 6 (1–3): 163–8. PMID 8395240.
• Kishimoto S, Shimadzu W, Izumi T, et al. (1996). "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils". J. Immunol. 157 (9): 4126–32. doi:10.4049/jimmunol.157.9.4126. PMID 8892648.
• Chase PB, Yang JM, Thompson FH, et al. (1997). "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 72 (2–3): 205–7. doi:10.1159/000134190. PMID 8978777.
• Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor". FEBS Lett. 402 (2–3): 203–8. doi:10.1016/S0014-5793(96)01531-1. PMID 9037196. S2CID 21074692.
• Ahmed A, Dearn S, Shams M, et al. (1998). "Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125". FASEB J. 12 (10): 831–43. doi:10.1096/fasebj.12.10.831. PMID 9657523. S2CID 17474972.
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. S2CID 195213008.

External links

• "Platelet-Activating Factor Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
• platelet+activating+factor+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.