TAS2R43

TAS2R43
Identifiers
Aliases	TAS2R43, T2R43, T2R52, taste 2 receptor member 43
External IDs	OMIM: 612668; MGI: 2681304; HomoloGene: 128798; GeneCards: TAS2R43; OMA:TAS2R43 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 11,091,287 bp[1] End 11,092,313 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G1|6 64.03 cM Start 132,754,142 bp[2] End 132,755,125 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle muscle of thigh tonsil Achilles tendon sural nerve apex of heart urinary bladder ganglionic eminence renal cortex ectocervix n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity taste receptor activity bitter taste receptor activity Cellular component plasma membrane cell projection motile cilium cilium membrane ciliary membrane integral component of membrane Biological process detection of chemical stimulus involved in sensory perception of bitter taste signal transduction response to stimulus sensory perception of taste G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 259289 353165 Ensembl ENSG00000255374 ENSG00000262612 ENSG00000282537 ENSMUSG00000053217 UniProt P59537 Q7TQA8 RefSeq (mRNA) NM_176884 NM_181276 RefSeq (protein) NP_795365 NP_851793 Location (UCSC) Chr 12: 11.09 – 11.09 Mb Chr 6: 132.75 – 132.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Taste receptor type 2 member 43 is a protein that in humans is encoded by the TAS2R43 gene.^[5][6]

See also

• Taste receptor

References

1. ENSG00000262612, ENSG00000282537 GRCh38: Ensembl release 89: ENSG00000255374, ENSG00000262612, ENSG00000282537 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053217 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.
6. "Entrez Gene: TAS2R43 taste receptor, type 2, member 43".

Further reading

• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. S2CID 37807140.
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520. S2CID 718601.
• Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet. Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440. S2CID 1542970.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
• Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W (2005). "Bitter taste receptors for saccharin and acesulfame K." J. Neurosci. 24 (45): 10260–5. doi:10.1523/JNEUROSCI.1225-04.2004. PMC 6730199. PMID 15537898.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.
• Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression". J. Biol. Chem. 281 (29): 20650–9. doi:10.1074/jbc.M513637200. PMID 16720576.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.