HTR3E

HTR3E
Identifiers
Aliases	HTR3E, 5-HT3-E, 5-HT3E, 5-HT3c1, 5-hydroxytryptamine receptor 3E
External IDs	OMIM: 610123; HomoloGene: 50735; GeneCards: HTR3E; OMA:HTR3E - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,097,064 bp[1] End 184,106,995 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon duodenum placenta rectum right lung prefrontal cortex muscle of thigh lymph node appendix white blood cell n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding extracellular ligand-gated ion channel activity serotonin-gated cation-selective channel activity ion channel activity transmembrane signaling receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane neuron projection synapse Biological process ion transport signal transduction ion transmembrane transport serotonin receptor signaling pathway chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 285242 n/a Ensembl ENSG00000186038 n/a UniProt A5X5Y0 n/a RefSeq (mRNA) NM_198314 NM_001256613 NM_001256614 NM_182589 NM_198313 n/a RefSeq (protein) NP_001243542 NP_001243543 NP_872395 NP_938055 NP_938056 n/a Location (UCSC) Chr 3: 184.1 – 184.11 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

5-hydroxytryptamine receptor 3E is a protein that in humans is encoded by the HTR3E gene.^[3][4] The protein encoded by this gene is a subunit of the 5-HT3 receptor.^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000186038 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene. 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637.
4. Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans. 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Karnovsky AM, Gotow LF, McKinley DD, et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3". Gene. 319: 137–48. doi:10.1016/S0378-1119(03)00803-5. PMID 14597179.
• Nalivaiko E, Sgoifo A (2009). "Central 5-HT receptors in cardiovascular control during stress". Neuroscience and Biobehavioral Reviews. 33 (2): 95–106. doi:10.1016/j.neubiorev.2008.05.026. PMID 18573276. S2CID 44767978.
• Kapeller J, Houghton LA, Mönnikes H, et al. (2008). "First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome". Hum. Mol. Genet. 17 (19): 2967–77. doi:10.1093/hmg/ddn195. PMID 18614545.

External links

• HTR3E+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)