GRIN2D

GRIN2D
Identifiers
Aliases	GRIN2D, EB11, GluN2D, NMDAR2D, NR2D, glutamate ionotropic receptor NMDA type subunit 2D, EIEE46, DEE46
External IDs	OMIM: 602717; MGI: 95823; HomoloGene: 648; GeneCards: GRIN2D; OMA:GRIN2D - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,444,931 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,878,378 bp
RNA expression pattern
	Top expressed in
	cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; ganglionic eminence; ; Hypothalamus; ; ventricular zone; ; right frontal lobe; ; lateral nuclear group of thalamus; ; Amygdala; ; dorsolateral prefrontal cortex;
	Top expressed in
	molecular layer of cerebellar cortex; ; lumbar subsegment of spinal cord; ; molar; ; primary visual cortex; ; seminiferous tubule; ; dorsomedial hypothalamic nucleus; ; superior frontal gyrus; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion channel activity; protein binding; extracellularly glutamate-gated ion channel activity; ionotropic glutamate receptor activity; NMDA glutamate receptor activity; glutamate-gated calcium ion channel activity; signaling receptor activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; intracellular anatomical structure; integral component of plasma membrane; NMDA selective glutamate receptor complex; postsynaptic density membrane;
Biological process	startle response; regulation of sensory perception of pain; adult locomotory behavior; ion transport; MAPK cascade; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; calcium-mediated signaling; calcium ion transmembrane import into cytosol; regulation of molecular function; brain development; regulation of synaptic plasticity; long-term potentiation; excitatory chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2906
	14814
	ENSG00000105464
	ENSMUSG00000002771
	O15399
	Q03391
	NM_000836
	NM_008172
	NP_000827
	NP_032198
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate [NMDA] receptor subunit epsilon-4 is a protein that in humans is encoded by the GRIN2D gene.^[5]^[6]^[7]

Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).^[7]

Interactions

GRIN2D has been shown to interact with Interleukin 16.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105464 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002771 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (Apr 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5. doi:10.1006/geno.1997.5132. PMID 9480759.
^ Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M (Jan 1998). "Isolation of estrogen-responsive genes with a CpG island library". Mol. Cell. Biol. 18 (1): 442–9. doi:10.1128/mcb.18.1.442. PMC 121513. PMID 9418891.
^ ^a ^b "Entrez Gene: GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D".
^ Kurschner C, Yuzaki M (Sep 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. 19 (18): 7770–80. doi:10.1523/JNEUROSCI.19-18-07770.1999. PMC 6782450. PMID 10479680.

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