CHRNB4

CHRNB4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ASG
Identifiers
Aliases	CHRNB4, cholinergic receptor nicotinic beta 4 subunit
External IDs	OMIM: 118509; MGI: 87892; HomoloGene: 20196; GeneCards: CHRNB4; OMA:CHRNB4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,727,754 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,956,063 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; right testis; ; left testis; ; ganglionic eminence; ; muscle layer of sigmoid colon; ; ventricular zone; ; sural nerve; ; right adrenal gland; ; appendix;
	Top expressed in
	habenula; ; lumbar spinal ganglion; ; pineal gland; ; ciliary body; ; pretectal area; ; iris; ; Paneth cell; ; embryo; ; adrenal gland; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine binding; acetylcholine receptor activity; ion channel activity; ligand-gated ion channel activity; protein heterodimerization activity; extracellular ligand-gated ion channel activity; protein binding; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	acetylcholine-gated channel complex; integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; neuron projection; specific granule membrane; tertiary granule membrane; cholinergic synapse;
Biological process	smooth muscle contraction; locomotory behavior; regulation of smooth muscle contraction; protein heterooligomerization; positive regulation of transmission of nerve impulse; regulation of membrane potential; response to nicotine; synaptic transmission, cholinergic; ion transport; regulation of neurotransmitter secretion; behavioral response to nicotine; synaptic transmission involved in micturition; action potential; signal transduction; neutrophil degranulation; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; ion transmembrane transport; chemical synaptic transmission; neuromuscular synaptic transmission; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	1143
	108015
	ENSG00000117971
	ENSMUSG00000035200
	P30926
	Q8R493
	NM_000750; NM_001256567
	NM_148944
	NP_000741; NP_001243496
	NP_683746
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene.^[5]^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. ^{[§ 1]}

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NicotineActivityonChromaffinCells_WP1603

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|alt=Nicotine Activity on Chromaffin Cells edit]]

Nicotine Activity on Chromaffin Cells edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117971 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035200 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–282. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
^ "Entrez Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4".

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Gerzanich V, Kuryatov A, Anand R, Lindstrom J (1997). ""Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor". Mol. Pharmacol. 51 (2): 320–7. doi:10.1124/mol.51.2.320. PMID 9203638.
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Lev-Lehman E, Bercovich D, Xu W, et al. (2001). "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4". J. Hum. Genet. 46 (7): 362–366. doi:10.1007/PL00010921. PMID 11450844.
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