GRIK5

GRIK5
Identifiers
Aliases	GRIK5, EAA2, GRIK2, GluK5, KA2, glutamate ionotropic receptor kainate type subunit 5
External IDs	OMIM: 600283; MGI: 95818; HomoloGene: 1578; GeneCards: GRIK5; OMA:GRIK5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,998,321 bp[1] End 42,070,206 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 13.73 cM Start 25,009,849 bp[2] End 25,072,346 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb lateral nuclear group of thalamus ventral tegmental area subthalamic nucleus vena cava superior vestibular nucleus inferior ganglion of vagus nerve Pons external globus pallidus pars compacta Top expressed in superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell entorhinal cortex perirhinal cortex CA3 field neural layer of retina olfactory tubercle ventricular zone primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutamate receptor activity PDZ domain binding kainate selective glutamate receptor activity SH3 domain binding ion channel activity ionotropic glutamate receptor activity identical protein binding extracellularly glutamate-gated ion channel activity ligand-gated ion channel activity signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane perikaryon postsynaptic membrane kainate selective glutamate receptor complex membrane postsynaptic density synapse cell junction terminal bouton axon dendrite soma endoplasmic reticulum neuron projection ionotropic glutamate receptor complex presynaptic membrane nucleus plasma membrane hippocampal mossy fiber to CA3 synapse glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane integral component of postsynaptic density membrane Biological process synaptic transmission, glutamatergic regulation of membrane potential ion transport receptor clustering protein retention in ER lumen regulation of synaptic vesicle fusion to presynaptic active zone membrane ion transmembrane transport positive regulation of neuron apoptotic process establishment of localization in cell ionotropic glutamate receptor signaling pathway excitatory postsynaptic potential cellular response to glucose stimulus chemical synaptic transmission modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2901 14809 Ensembl ENSG00000105737 ENSMUSG00000003378 UniProt Q16478 Q61626 RefSeq (mRNA) NM_001301030 NM_002088 NM_008168 NM_001360067 RefSeq (protein) NP_001287959 NP_002079 NP_032194 NP_001346996 NP_001389776 NP_001389777 NP_001389778 Location (UCSC) Chr 19: 42 – 42.07 Mb Chr 7: 25.01 – 25.07 Mb PubMed search [3] [4]
Wikidata
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Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.^[5][6]

Function

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.^[6]

Interactions

GRIK5 has been shown to interact with DLG4^[7][8] and GRIK2.^[9][10]

See also

• Kainate receptor

References

1. GRCh38: Ensembl release 89: ENSG00000105737 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003378 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG, et al. (January 1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A. 91 (25): 11849–53. Bibcode:1994PNAS...9111849S. doi:10.1073/pnas.91.25.11849. PMC 45333. PMID 7527545.
6. "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5".
7. Mehta S, Wu H, Garner CC, Marshall J (May 2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.
8. Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J (October 1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron. 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460. S2CID 18723258.
9. Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS (January 1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. 269 (2): 1332–9. doi:10.1016/S0021-9258(17)42262-9. PMID 8288598.
10. Ripellino JA, Neve RL, Howe JR (January 1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. S2CID 23219004.

Further reading

• Kamboj RK, Schoepp DD, Nutt S, et al. (1992). "Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit". Mol. Pharmacol. 42 (1): 10–5. PMID 1321949.
• Cauley K, Kukekov V, Young D (1997). "Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture". J. Neurosci. Res. 47 (3): 311–21. doi:10.1002/(SICI)1097-4547(19970201)47:3<311::AID-JNR9>3.0.CO;2-L. PMID 9039653. S2CID 13044525.
• Porter RH, Eastwood SL, Harrison PJ (1997). "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia". Brain Res. 751 (2): 217–31. doi:10.1016/S0006-8993(96)01404-7. PMID 9099808. S2CID 9796632.
• Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. S2CID 23219004.
• Garcia EP, Mehta S, Blair LA, et al. (1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron. 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460. S2CID 18723258.
• Mehta S, Wu H, Garner CC, Marshall J (2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kohda K, Kamiya Y, Matsuda S, et al. (2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): 27–37. doi:10.1016/S0169-328X(02)00561-2. PMID 12573530.
• Hayes DM, Braud S, Hurtado DE, et al. (2003). "Trafficking and surface expression of the glutamate receptor subunit, KA2". Biochem. Biophys. Res. Commun. 310 (1): 8–13. doi:10.1016/j.bbrc.2003.08.115. PMID 14511640.
• Kamm C, Leung J, Joseph S, et al. (2004). "Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene". Mov. Disord. 19 (7): 845–7. doi:10.1002/mds.20095. PMID 15254951. S2CID 20276163.

External links

• GRIK5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.