HTR3A

HTR3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PIR
Identifiers
Aliases	HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A
External IDs	OMIM: 182139; MGI: 96282; HomoloGene: 671; GeneCards: HTR3A; OMA:HTR3A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	113,990,313 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	48,822,399 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; testicle; ; trigeminal ganglion; ; lymph node; ; islet of Langerhans; ; appendix; ; gingival epithelium; ; muscle layer of sigmoid colon; ; caudate nucleus; ; minor salivary glands;
	Top expressed in
	lumbar spinal ganglion; ; Rostral migratory stream; ; facial motor nucleus; ; medial ganglionic eminence; ; right ventricle; ; embryo; ; carotid body; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; retinal pigment epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ligand-gated ion channel activity; serotonin binding; extracellular ligand-gated ion channel activity; serotonin-gated cation-selective channel activity; ion channel activity; transmembrane signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; axon; cell junction; soma; serotonin-activated cation-selective channel complex; cleavage furrow; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of plasma membrane; neuron projection;
Biological process	response to cocaine; cellular response to growth factor stimulus; ion transport; response to ethanol; positive regulation of ion transmembrane transporter activity; signal transduction; ion transmembrane transport; serotonin receptor signaling pathway; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	3359
	15561
	ENSG00000166736
	ENSMUSG00000032269
	P46098
	P23979
	NM_000869; NM_001161772; NM_213621
	NM_001099644; NM_013561
	NP_000860; NP_001155244; NP_998786
	NP_001093114; NP_038589
	Wikidata
View/Edit Human	View/Edit Mouse

5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.^[5]^[6]

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166736 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032269 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (Feb 1996). "Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2". Genomics. 29 (1): 304–305. doi:10.1006/geno.1995.1254. PMID 8530095.
^ Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (Jul 2003). "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors". Nature. 424 (6946): 321–324. Bibcode:2003Natur.424..321K. doi:10.1038/nature01788. PMID 12867984. S2CID 4417817.
^ "Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A".

Miyake A, Mochizuki S, Takemoto Y, Akuzawa S (1995). "Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species". Mol. Pharmacol. 48 (3): 407–416. doi:10.1016/S0026-895X(25)10488-4. PMID 7565620.
Uetz P, Abdelatty F, Villarroel A, et al. (1994). "Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11". FEBS Lett. 339 (3): 302–306. Bibcode:1994FEBSL.339..302U. doi:10.1016/0014-5793(94)80435-4. PMID 8112471. S2CID 28979681.
Belelli D, Balcarek JM, Hope AG, et al. (1996). "Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit". Mol. Pharmacol. 48 (6): 1054–1062. doi:10.1016/S0026-895X(25)10574-9. PMID 8848005.
Brüss M, Göthert M, Hayer M, Bönisch H (1999). "Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs". Ann. N. Y. Acad. Sci. 861: 234–235. doi:10.1111/j.1749-6632.1998.tb10196.x. PMID 9928262.
Davies PA, Pistis M, Hanna MC, et al. (1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–363. Bibcode:1999Natur.397..359D. doi:10.1038/16941. PMID 9950429. S2CID 4401851.
Brüss M, Eucker T, Göthert M, Bönisch H (2000). "Exon-intron organization of the human 5-HT3A receptor gene". Neuropharmacology. 39 (2): 308–315. doi:10.1016/S0028-3908(99)00116-1. PMID 10670426. S2CID 6002534.
Marazziti D, Betti L, Giannaccini G, et al. (2002). "Distribution of [3H]GR65630 binding in human brain postmortem". Neurochem. Res. 26 (3): 187–190. doi:10.1023/A:1010939530412. PMID 11495540. S2CID 2548479.
Spier AD, Lummis SC (2003). "Immunological characterization of 5-HT3 receptor transmembrane topology". J. Mol. Neurosci. 18 (3): 169–178. doi:10.1385/JMN:18:3:169. PMID 12059035. S2CID 25754984.
Boyd GW, Low P, Dunlop JI, et al. (2002). "Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins". Mol. Cell. Neurosci. 21 (1): 38–50. doi:10.1006/mcne.2002.1160. PMID 12359150. S2CID 37832903.
Hapfelmeier G, Haseneder R, Lampadius K, et al. (2003). "Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics". Neurosci. Lett. 335 (1): 44–48. doi:10.1016/S0304-3940(02)01156-4. PMID 12457738. S2CID 35192275.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pick H, Preuss AK, Mayer M, et al. (2003). "Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells". Biochemistry. 42 (4): 877–884. doi:10.1021/bi026576d. PMID 12549905.
Choi S, Lee JH, Oh S, et al. (2003). "Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes". Mol. Cells. 15 (1): 108–113. doi:10.1016/S1016-8478(23)13715-0. PMID 12661769.
Boyd GW, Doward AI, Kirkness EF, et al. (2003). "Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal". J. Biol. Chem. 278 (30): 27681–27687. doi:10.1074/jbc.M304938200. PMID 12750374.
Sun H, Hu XQ, Moradel EM, et al. (2003). "Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C". J. Biol. Chem. 278 (36): 34150–34157. doi:10.1074/jbc.M303584200. PMID 12791692.
Maksay G, Bikádi Z, Simonyi M (2004). "Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models". J. Recept. Signal Transduct. Res. 23 (2–3): 255–270. doi:10.1081/RRS-120025568. PMID 14626451. S2CID 26799630.
Kaiser R, Tremblay PB, Sezer O, et al. (2004). "Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists". Pharmacogenetics. 14 (5): 271–278. doi:10.1097/00008571-200405000-00001. PMID 15115912.
Panicker S, Cruz H, Arrabit C, et al. (2004). "Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor". J. Biol. Chem. 279 (27): 28149–28158. doi:10.1074/jbc.M403545200. PMID 15131114.