GLRA3

GLRA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CFB
Identifiers
Aliases	GLRA3, glycine receptor alpha 3
External IDs	OMIM: 600421; MGI: 95749; HomoloGene: 142; GeneCards: GLRA3; OMA:GLRA3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q34.1 Start 174,636,920 bp[1] End 174,829,247 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B2|8 29.69 cM Start 56,393,495 bp[2] End 56,583,105 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle pancreatic ductal cell prefrontal cortex islet of Langerhans gonad Brodmann area 9 cingulate gyrus anterior cingulate cortex right frontal lobe hypothalamus Top expressed in substantia nigra ventromedial nucleus ventral tegmental area anterior amygdaloid area dorsomedial hypothalamic nucleus superior colliculus paraventricular nucleus of hypothalamus lumbar subsegment of spinal cord lateral hypothalamus utricle More reference expression data BioGPS n/a
Gene ontology Molecular function glycine-gated chloride ion channel activity glycine binding metal ion binding transmitter-gated ion channel activity chloride channel activity extracellular ligand-gated ion channel activity extracellularly glycine-gated chloride channel activity ion channel activity transmembrane signaling receptor activity Cellular component integral component of membrane perikaryon postsynaptic membrane cell projection membrane plasma membrane synapse integral component of plasma membrane chloride channel complex glycine-gated chloride channel complex cell junction dendrite neuron projection Biological process response to amino acid chloride transmembrane transport ion transport synaptic transmission, glycinergic chloride transport neuropeptide signaling pathway protein homooligomerization excitatory postsynaptic potential ion transmembrane transport signal transduction chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8001 110304 Ensembl ENSG00000145451 ENSMUSG00000038257 UniProt O75311 Q91XP5 RefSeq (mRNA) NM_001042543 NM_006529 NM_080438 NM_001368774 RefSeq (protein) NP_001036008 NP_006520 NP_536686 NP_001355703 Location (UCSC) Chr 4: 174.64 – 174.83 Mb Chr 8: 56.39 – 56.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The Glycine receptor subunit alpha-3 is a protein that in humans is encoded by the GLRA3 gene.^[5] The protein encoded by this gene is a subunit of the glycine receptor.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000145451 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038257 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nikolic Z, Laube B, Weber RG, Lichter P, Kioschis P, Poustka A, Mulhardt C, Becker CM (Sep 1998). "The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts". J Biol Chem. 273 (31): 19708–14. doi:10.1074/jbc.273.31.19708. PMID 9677400.

Further reading

• Breitinger HG, Villmann C, Rennert J, et al. (2002). "Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels". J. Neurochem. 83 (1): 30–6. doi:10.1046/j.1471-4159.2002.01109.x. PMID 12358726. S2CID 15091954.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.

External links

• GLRA3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycine receptor subunit alpha-3 (GLRA3)