Frizzled-1

FZD1
Identifiers
Aliases	FZD1, frizzled class receptor 1
External IDs	OMIM: 603408; MGI: 1196625; HomoloGene: 20750; GeneCards: FZD1; OMA:FZD1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.13 Start 91,264,433 bp[1] End 91,271,326 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A1|5 2.61 cM Start 4,803,839 bp[2] End 4,808,035 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lactiferous duct visceral pleura tail of epididymis tendon of biceps brachii Epithelium of choroid plexus parietal pleura trigeminal ganglion superficial temporal artery hair follicle spinal ganglia Top expressed in gastrula calvaria vas deferens umbilical cord habenula hair follicle aortic valve decidua ascending aorta endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding frizzled binding signal transducer activity Wnt-protein binding protein binding Wnt-activated receptor activity signaling receptor binding transmembrane signaling receptor activity G protein-coupled receptor activity Cellular component Wnt signalosome membrane focal adhesion plasma membrane cell surface integral component of membrane Biological process G protein-coupled receptor signaling pathway positive regulation of protein phosphorylation autocrine signaling epithelial cell differentiation muscular septum morphogenesis ventricular septum morphogenesis cell-cell signaling membranous septum morphogenesis outflow tract morphogenesis positive regulation of DNA-binding transcription factor activity Wnt signaling pathway planar cell polarity pathway involved in neural tube closure negative regulation of BMP signaling pathway positive regulation of transcription, DNA-templated multicellular organism development cell surface receptor signaling pathway canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation hard palate development neuron differentiation canonical Wnt signaling pathway negative regulation of transcription, DNA-templated signal transduction Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation beta-catenin destruction complex disassembly Wnt signaling pathway, planar cell polarity pathway presynapse assembly negative regulation of oxidative stress-induced neuron death non-canonical Wnt signaling pathway positive regulation of neuron projection development negative regulation of canonical Wnt signaling pathway regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8321 14362 Ensembl ENSG00000157240 ENSMUSG00000044674 UniProt Q9UP38 O70421 RefSeq (mRNA) NM_003505 NM_021457 RefSeq (protein) NP_003496 NP_067432 Location (UCSC) Chr 7: 91.26 – 91.27 Mb Chr 5: 4.8 – 4.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Frizzled-1 (Fz-1) is a protein that in humans is encoded by the FZD1 gene.^[5][6]

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000157240 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044674 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
6. "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)".

Further reading

• Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
• Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA (Oct 1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
• DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (May 2002). "The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor". Naunyn-Schmiedeberg's Archives of Pharmacology. 365 (5): 341–8. doi:10.1007/s00210-002-0540-3. PMID 12012019. S2CID 8192909.
• Hering H, Sheng M (Jun 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Letters. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. S2CID 39243103.
• Zilberberg A, Yaniv A, Gazit A (Apr 2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". The Journal of Biological Chemistry. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301.
• Wu J, Klein TJ, Mlodzik M (Jul 2004). "Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity". PLOS Biology. 2 (7): E158. doi:10.1371/journal.pbio.0020158. PMC 449784. PMID 15252441.
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
• Yang L, Yamasaki K, Shirakata Y, Dai X, Tokumaru S, Yahata Y, Tohyama M, Hanakawa Y, Sayama K, Hashimoto K (May 2006). "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". Journal of Dermatological Science. 42 (2): 111–9. doi:10.1016/j.jdermsci.2005.12.011. PMID 16442268.

External links

• "Frizzled Receptors: FZD₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.