Neuromedin U receptor 1

NMUR1
Identifiers
Aliases	NMUR1, (FM-3), FM-3, FM3, GPC-R, GPR66, NMU1R, Neuromedin U receptor 1
External IDs	OMIM: 604153; MGI: 1341898; HomoloGene: 68501; GeneCards: NMUR1; OMA:NMUR1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 231,523,187 bp[1] End 231,530,445 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 86,314,025 bp[2] End 86,353,950 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte gonad testicle blood right lung body of pancreas spleen subcutaneous adipose tissue monocyte right uterine tube Top expressed in right ventricle seminiferous tubule duodenum cerebellar cortex jejunum ileum respiratory system lower respiratory tract lung foregut More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuromedin U receptor activity G protein-coupled receptor activity signal transducer activity neuropeptide receptor activity neuromedin U binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane intracellular anatomical structure Biological process smooth muscle contraction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway chloride transport inositol phosphate-mediated signaling activation of phospholipase C activity calcium ion transport calcium-mediated signaling signal transduction neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10316 14767 Ensembl ENSG00000171596 ENSMUSG00000026237 UniProt Q9HB89 O55040 RefSeq (mRNA) NM_006056 NM_010341 NM_001319227 RefSeq (protein) NP_006047 NP_001306156 NP_034471 Location (UCSC) Chr 2: 231.52 – 231.53 Mb Chr 1: 86.31 – 86.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuromedin-U receptor 1 is a protein that in humans is encoded by the NMUR1 gene.^[5][6]

See also

• Neuromedin U receptor
• Limostatin

References

1. GRCh38: Ensembl release 89: ENSG00000171596 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026237 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Hreniuk DL, Smith RG, Howard AD (Dec 1998). "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors". Genomics. 52 (2): 223–9. doi:10.1006/geno.1998.5441. PMID 9782091.
6. "Entrez Gene: NMUR1 neuromedin U receptor 1".

Further reading

• Fujii R, Hosoya M, Fukusumi S, et al. (2000). "Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3". J. Biol. Chem. 275 (28): 21068–74. doi:10.1074/jbc.M001546200. PMID 10783389.
• Szekeres PG, Muir AI, Spinage LD, et al. (2000). "Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3". J. Biol. Chem. 275 (27): 20247–50. doi:10.1074/jbc.C000244200. PMID 10811630.
• Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system". J. Biol. Chem. 275 (42): 32452–9. doi:10.1074/jbc.M004613200. PMID 10899166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mori K, Miyazato M, Ida T, et al. (2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system". EMBO J. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.

External links

• "Neuromedin U Receptors: NMU1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2015-04-02. Retrieved 2008-12-05.
• NMUR1 human gene location in the UCSC Genome Browser.
• NMUR1 human gene details in the UCSC Genome Browser.