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GPR146
Identifiers
Aliases	GPR146, PGR8, G protein-coupled receptor 146
External IDs	MGI: 1933113; HomoloGene: 36472; GeneCards: GPR146; OMA:GPR146 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	1,059,261 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,396,415 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; abdominal fat; ; apex of heart; ; gastric mucosa; ; right lung; ; tibial nerve; ; blood; ; left ventricle; ; body of stomach; ; upper lobe of left lung;
	Top expressed in
	interventricular septum; ; retinal pigment epithelium; ; muscle of thigh; ; myocardium of ventricle; ; left lobe of liver; ; right lung; ; triceps brachii muscle; ; right kidney; ; right lung lobe; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	115330
	80290
	ENSG00000164849
	ENSMUSG00000044197
	Q96CH1
	Q99LE2
	NM_001303473; NM_001303474; NM_138445
	NM_001038703; NM_030258
	NP_001290402; NP_001290403; NP_612454
	NP_001033792; NP_084534; NP_001349135
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene.^[5] The receptor has been shown to bind cholesin/C17orf50, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. ^[6] Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions.^[7] GPR146 has also been identified as a possible receptor for C-peptide.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164849 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044197 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR146 G protein-coupled receptor 146".
^ Hu X, Chen F, Jia L, Long A, Peng Y, Li X; et al. (2024). "A gut-derived hormone regulates cholesterol metabolism". Cell. 187 (7): 1685-1700.e18. doi:10.1016/j.cell.2024.02.024. PMID 38503280.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F; et al. (2019). "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis". Cell. 179 (6): 1276-1288.e14. doi:10.1016/j.cell.2019.10.034. PMC 6889877. PMID 31778654.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Yosten GL, Kolar GR, Redlinger LJ, Samson WK (11 July 2013). "Evidence for an interaction between proinsulin C-peptide and GPR146". The Journal of Endocrinology. 218 (2): B1-8. doi:10.1530/JOE-13-0203. PMID 23759446.

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Gloriam DE, Schiöth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta (BBA) - General Subjects. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.