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GPR42
Identifiers
Aliases	GPR42, FFAR1L, FFAR3L, GPR41L, GPR42P, G protein-coupled receptor 42 (gene/pseudogene), G protein-coupled receptor 42
External IDs	OMIM: 603822; MGI: 2685324; GeneCards: GPR42; OMA:GPR42 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,372,962 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,555,603 bp
RNA expression pattern
	Top expressed in
	blood; ; muscle layer of sigmoid colon; ; muscle of thigh; ; islet of Langerhans; ; appendix; ; subcutaneous adipose tissue; ; urinary bladder; ; lactiferous gland; ; gallbladder; ; muscle tissue;
	Top expressed in
	islet of Langerhans; ; embryo; ; blastocyst; ; nerve trunk; ; proximal tubule; ; autonomic nervous system; ; right kidney; ; sympathetic nervous system; ; sympathetic ganglion; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2866
	233080
	ENSG00000126251
	ENSMUSG00000019429
	O15529
	Q3UFD7
	NM_005305; NM_001348195
	NM_001033316
	NP_001335124
	NP_001028488
	Wikidata
View/Edit Human	View/Edit Mouse

Putative G-protein coupled receptor 42 (previously termed FFAR1L, FFAR3L, GPR41L, and GPR42P) is a protein that in humans is encoded by the GPR42 gene.^[5]^[6] The human GPR gene is located at the same site as the human FFAR1, FFAR, and FFAR3 genes, i.e., on the long (i.e., "q") arm of chromosome 19 at position 23.33 (notated as 19q23.33). This gene appears to be a segmental duplication of the FFAR3 gene. The human GPR42 gene codes for several proteins with a FFAR3-like structure but their expression in various cell types and tissues as well as their activities and functions have not yet been clearly defined in any scientific publication followed by PubMed as of 2023.^[7]^[8]^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126251 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019429 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, O'Dowd BF (Nov 1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochem Biophys Res Commun. 239 (2): 543–7. doi:10.1006/bbrc.1997.7513. PMID 9344866.
^ "Entrez Gene: GPR42 G protein-coupled receptor 42".
^ Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ (March 2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids". The Journal of Biological Chemistry. 278 (13): 11312–9. doi:10.1074/jbc.M211609200. PMID 12496283.
^ Liaw CW, Connolly DT (November 2009). "Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42". DNA and Cell Biology. 28 (11): 555–60. doi:10.1089/dna.2009.0916. PMID 19630535.
^ Puhl HL, Won YJ, Lu VB, Ikeda SR (August 2015). "Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed". Scientific Reports. 5: 12880. Bibcode:2015NatSR...512880P. doi:10.1038/srep12880. PMC 4531286. PMID 26260360.
^ Pluznick JL (April 2017). "Microbial Short-Chain Fatty Acids and Blood Pressure Regulation". Current Hypertension Reports. 19 (4): 25. doi:10.1007/s11906-017-0722-5. PMC 5584783. PMID 28315048.

External links

"Free Fatty Acid Receptors: GPR42". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.