LPAR3

LPAR3
Identifiers
Aliases	LPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDs	OMIM: 605106; MGI: 1929469; HomoloGene: 8123; GeneCards: LPAR3; OMA:LPAR3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 84,811,602 bp[1] End 84,893,206 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 H2|3 71.03 cM Start 145,926,718 bp[2] End 145,991,941 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right uterine tube mucosa of paranasal sinus spinal ganglia olfactory zone of nasal mucosa trigeminal ganglion atrium right auricle myocardium cardiac muscle tissue of right atrium Top expressed in lumbar spinal ganglion endocardial cushion right kidney membranous bone Dermatocranium maxilla mandible vestibular membrane of cochlear duct atrioventricular junction atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity lysophosphatidic acid receptor activity G-protein alpha-subunit binding phospholipid binding lipid binding Cellular component integral component of membrane membrane integral component of plasma membrane axon plasma membrane Biological process chemical synaptic transmission positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger bleb assembly positive regulation of collateral sprouting signal transduction positive regulation of MAPK cascade positive regulation of calcium ion transport G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23566 65086 Ensembl ENSG00000171517 ENSMUSG00000036832 UniProt Q9UBY5 Q9EQ31 RefSeq (mRNA) NM_012152 NM_022983 RefSeq (protein) NP_036284 NP_075359 Location (UCSC) Chr 1: 84.81 – 84.89 Mb Chr 3: 145.93 – 145.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein that in humans is encoded by the LPAR3 gene.^[5][6] LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[7]

Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.^[5]

Evolution

Paralogues

Source:^[8]

• LPAR1
• LPAR2
• S1PR1
• S1PR3
• S1PR4
• S1PR2
• S1PR5
• CNR1
• GPR3
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• MC3R
• MC1R
• MC2R
• GPR119

See also

• Lysophospholipid receptor

References

1. GRCh38: Ensembl release 89: ENSG00000171517 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036832 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3".
6. Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999). "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid". J. Biol. Chem. 274 (39): 27776–85. doi:10.1074/jbc.274.39.27776. PMID 10488122.
7. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
8. "GeneCards®: The Human Gene Database".

Further reading

• Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors". Mol. Pharmacol. 58 (6): 1188–96. doi:10.1124/mol.58.6.1188. PMID 11093753. S2CID 6936621.
• Im DS, Heise CE, Harding MA, et al. (2000). "Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate". Mol. Pharmacol. 57 (4): 753–9. doi:10.1124/mol.57.4.753. PMID 10727522.
• Fitzgerald LR, Dytko GM, Sarau HM, et al. (2000). "Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 273 (3): 805–10. doi:10.1006/bbrc.2000.2943. PMID 10891327.
• Tokumura A, Sinomiya J, Kishimoto S, et al. (2002). "Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids". Biochem. J. 365 (Pt 3): 617–28. doi:10.1042/BJ20020348. PMC 1222725. PMID 11982483.
• Hama K, Bandoh K, Kakehi Y, et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors". FEBS Lett. 523 (1–3): 187–92. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830. S2CID 44924895.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cremers B, Flesch M, Kostenis E, et al. (2003). "Modulation of myocardial contractility by lysophosphatidic acid (LPA)". J. Mol. Cell. Cardiol. 35 (1): 71–80. doi:10.1016/S0022-2828(02)00279-1. PMID 12623301.
• Fujita T, Miyamoto S, Onoyama I, et al. (2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer". Cancer Lett. 192 (2): 161–9. doi:10.1016/S0304-3835(02)00713-9. PMID 12668280.
• Jin Y, Knudsen E, Wang L, Maghazachi AA (2003). "Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization". Eur. J. Immunol. 33 (8): 2083–9. doi:10.1002/eji.200323711. PMID 12884281. S2CID 41960806.
• Xing Y, Ganji SH, Noh JW, Kamanna VS (2005). "Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth". Am. J. Physiol. Renal Physiol. 287 (6): F1250–7. doi:10.1152/ajprenal.00342.2003. PMID 15292052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• "Lysophospholipid Receptors: LPA₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.