Sp3 transcription factor

SP3
Identifiers
Aliases	SP3, SPR2, Sp3 transcription factor
External IDs	OMIM: 601804; MGI: 1277166; HomoloGene: 7952; GeneCards: SP3; OMA:SP3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 173,880,850 bp[1] End 173,965,373 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 72,766,771 bp[2] End 72,810,790 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle germinal epithelium sural nerve superficial temporal artery mucosa of paranasal sinus Achilles tendon buccal mucosa cell skin of hip palpebral conjunctiva ventricular zone Top expressed in granulocyte genital tubercle left lung lobe migratory enteric neural crest cell hand thymus atrium dermis left colon ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin binding cis-regulatory region sequence-specific DNA binding metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific double-stranded DNA binding DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component PML body transcription repressor complex nucleus nucleoplasm protein-DNA complex Biological process megakaryocyte differentiation regulation of transcription, DNA-templated ossification lung development embryonic placenta development in utero embryonic development negative regulation of transcription by RNA polymerase II monocyte differentiation protein sumoylation transcription, DNA-templated embryonic skeletal system development positive regulation of transcription, DNA-templated embryonic process involved in female pregnancy T cell differentiation granulocyte differentiation embryonic camera-type eye morphogenesis trophectodermal cell differentiation enucleate erythrocyte differentiation erythrocyte differentiation definitive hemopoiesis liver development B cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II natural killer cell differentiation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6670 20687 Ensembl ENSG00000172845 ENSMUSG00000027109 UniProt Q02447 Q86TP0 O70494 RefSeq (mRNA) NM_003111 NM_001017371 NM_001172712 NM_001018042 NM_001098425 NM_011450 RefSeq (protein) NP_001017371 NP_001166183 NP_003102 NP_003102.1 NP_001018052 NP_001091895 Location (UCSC) Chr 2: 173.88 – 173.97 Mb Chr 2: 72.77 – 72.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Not to be confused with Sp³ bond.

Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.^[5]

Interactions

Sp3 transcription factor has been shown to interact with Histone deacetylase 2,^[6][7] PIAS1,^[8] E2F1^[9] and GABPA.^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000172845 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027109 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SP3 Sp3 transcription factor".
6. Won, Jaejoon; Yim Jeongbin; Kim Tae Kook (October 2002). "Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells". J. Biol. Chem. 277 (41): 38230–8. doi:10.1074/jbc.M206064200. ISSN 0021-9258. PMID 12151407.
7. Sun, Jian-Min; Chen Hou Yu; Moniwa Mariko; Litchfield David W; Seto Edward; Davie James R (September 2002). "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2". J. Biol. Chem. 277 (39): 35783–6. doi:10.1074/jbc.C200378200. ISSN 0021-9258. PMID 12176973.
8. Sapetschnig, Alexandra; Rischitor Grigore; Braun Harald; Doll Andreas; Schergaut Marion; Melchior Frauke; Suske Guntram (October 2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. 21 (19): 5206–15. doi:10.1093/emboj/cdf510. ISSN 0261-4189. PMC 129032. PMID 12356736.
9. Rotheneder, H; Geymayer S; Haidweger E (November 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. ISSN 0022-2836. PMID 10547281.
10. Galvagni, F; Capo S; Oliviero S (March 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter" (PDF). J. Mol. Biol. 306 (5): 985–96. doi:10.1006/jmbi.2000.4335. hdl:2318/141203. ISSN 0022-2836. PMID 11237613.

Further reading

• Tseng L, Gao J, Mazella J, et al. (1997). "Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium". Ann. N. Y. Acad. Sci. 828 (1): 27–37. Bibcode:1997NYASA.828...27T. doi:10.1111/j.1749-6632.1997.tb48521.x. PMID 9329821. S2CID 1601677.
• Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". J. Steroid Biochem. Mol. Biol. 85 (2–5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729. S2CID 28512341.