ERF (gene)

ERF
Identifiers
Aliases	ERF, CRS4, PE-2, PE2, ETS2 repressor factor, CHYTS
External IDs	OMIM: 611888; MGI: 109637; HomoloGene: 68516; GeneCards: ERF; OMA:ERF - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 42,247,569 bp[1] End 42,255,128 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 13.73 cM Start 25,242,561 bp[2] End 25,250,761 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube gastric mucosa gallbladder left uterine tube ventricular zone olfactory zone of nasal mucosa anterior pituitary body of uterus tibial nerve right ovary Top expressed in genital tubercle tail of embryo yolk sac ventricular zone lip superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell epiblast perirhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription corepressor activity DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II mitotic cell cycle regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2077 13875 Ensembl ENSG00000105722 ENSMUSG00000040857 UniProt P50548 P70459 RefSeq (mRNA) NM_001301035 NM_001308402 NM_001312656 NM_006494 NM_010155 RefSeq (protein) NP_001287964 NP_001295331 NP_001299585 NP_006485 NP_034285 Location (UCSC) Chr 19: 42.25 – 42.26 Mb Chr 7: 25.24 – 25.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.^[5][6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000105722 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040857 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sgouras DN, Athanasiou MA, Beal GJ, Fisher RJ, Blair DG, Mavrothalassitis GJ (October 1995). "ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation". The EMBO Journal. 14 (19): 4781–93. doi:10.1002/j.1460-2075.1995.tb00160.x. PMC 394576. PMID 7588608.
6. de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE (June 1997). "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)". Genomics. 42 (2): 227–35. doi:10.1006/geno.1997.4730. PMID 9192842.
7. "Entrez Gene: ERF Ets2 repressor factor".

Further reading

• Liu D, Pavlopoulos E, Modi W, Moschonas N, Mavrothalassitis G (March 1997). "ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes". Oncogene. 14 (12): 1445–51. doi:10.1038/sj.onc.1200965. PMID 9136988.
• Le Gallic L, Sgouras D, Beal G, Mavrothalassitis G (June 1999). "Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation". Molecular and Cellular Biology. 19 (6): 4121–33. doi:10.1128/mcb.19.6.4121. PMC 104371. PMID 10330152.
• Dintilhac A, Bernués J (March 2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". The Journal of Biological Chemistry. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. hdl:10261/112516. PMID 11748221.
• Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. Bibcode:2002FEBSL.517..167D. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.
• Bain M, Mendelson M, Sinclair J (January 2003). "Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells". The Journal of General Virology. 84 (Pt 1): 41–9. doi:10.1099/vir.0.18633-0. PMID 12533699.
• Xiao X, Athanasiou M, Sidorov IA, Horikawa I, Cremona G, Blair D, Barret JC, Dimitrov DS (December 2003). "Role of Ets/Id proteins for telomerase regulation in human cancer cells". Experimental and Molecular Pathology. 75 (3): 238–47. doi:10.1016/S0014-4800(03)00092-3. PMID 14611815.
• Wolvetang EJ, Bradfield OM, Hatzistavrou T, Crack PJ, Busciglio J, Kola I, Hertzog PJ (December 2003). "Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis". Neurobiology of Disease. 14 (3): 349–56. doi:10.1016/S0969-9961(03)00107-4. PMID 14678752. S2CID 30142532.
• Le Gallic L, Virgilio L, Cohen P, Biteau B, Mavrothalassitis G (February 2004). "ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression". Molecular and Cellular Biology. 24 (3): 1206–18. doi:10.1128/MCB.24.3.1206-1218.2004. PMC 321421. PMID 14729966.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass CK (July 2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS". Cell Cycle. 6 (13): 1594–604. doi:10.4161/cc.6.13.4336. PMID 17525531.
• Verykokakis M, Papadaki C, Vorgia E, Le Gallic L, Mavrothalassitis G (October 2007). "The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression". The Journal of Biological Chemistry. 282 (41): 30285–94. doi:10.1074/jbc.M704428200. PMID 17699159.

External links

• ERF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.