MEF2D

MEF2D
Identifiers
Aliases	MEF2D, myocyte enhancer factor 2D
External IDs	OMIM: 600663; MGI: 99533; HomoloGene: 4327; GeneCards: MEF2D; OMA:MEF2D - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,463,727 bp[1] End 156,500,779 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.78 cM Start 88,049,679 bp[2] End 88,079,393 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle popliteal artery tibial arteries saphenous vein apex of heart sural nerve gastric mucosa canal of the cervix right coronary artery Top expressed in Ileal epithelium neural layer of retina perirhinal cortex entorhinal cortex CA3 field muscle of thigh dentate gyrus of hippocampal formation granule cell superior frontal gyrus plantaris muscle primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity protein homodimerization activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific histone deacetylase binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein heterodimerization activity enzyme binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm intracellular membrane-bounded organelle nucleoplasm nucleus Biological process cell differentiation regulation of transcription, DNA-templated chondrocyte differentiation adult heart development muscle organ development endochondral ossification transcription by RNA polymerase II transcription, DNA-templated nervous system development multicellular organism development positive regulation of transcription, DNA-templated osteoblast differentiation skeletal muscle cell differentiation positive regulation of transcription by RNA polymerase II apoptotic process positive regulation of vascular associated smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4209 17261 Ensembl ENSG00000116604 ENSMUSG00000001419 UniProt Q14814 Q63943 RefSeq (mRNA) NM_001271629 NM_005920 NM_133665 NM_001310587 NM_001310593 RefSeq (protein) NP_001258558 NP_005911 NP_001297516 NP_001297522 NP_598426 Location (UCSC) Chr 1: 156.46 – 156.5 Mb Chr 3: 88.05 – 88.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.^[5][6]

Interactions

MEF2D has been shown to interact with:

• CABIN1,^[7][8]
• EP300,^[9][7]
• MAPK7,^[10]
• Myocyte-specific enhancer factor 2A,^[11]
• NFATC2^[12]
• Sp1 transcription factor,^[13] and
• YWHAQ.^[14]

See also

• Mef2

References

1. GRCh38: Ensembl release 89: ENSG00000116604 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001419 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–1106. doi:10.1242/dev.118.4.1095. PMID 8269842.
6. "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)".
7. Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.
8. Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–793. doi:10.1126/science.286.5440.790. PMID 10531067.
9. Youn HD, Grozinger CM, Liu JO (Jul 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry. 275 (29): 22563–22567. doi:10.1074/jbc.C000304200. PMID 10825153.
10. Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771–4777. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
11. Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry. 271 (40): 24927–24933. doi:10.1074/jbc.271.40.24927. PMID 8798771.
12. Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–4331. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.
13. Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/s0161-5890(02)00055-x. PMID 12213324.
14. Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research. 29 (13): 2836–2842. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030.

Further reading

• Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL (Oct 1995). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics. 29 (3): 704–711. doi:10.1006/geno.1995.9007. PMID 8575763.
• Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry. 271 (40): 24927–24933. doi:10.1074/jbc.271.40.24927. PMID 8798771.
• Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771–4777. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
• Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J (Jan 1999). "Regulation of the MEF2 family of transcription factors by p38". Molecular and Cellular Biology. 19 (1): 21–30. doi:10.1128/mcb.19.1.21. PMC 83862. PMID 9858528.
• Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (Nov 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Molecular and Cellular Biology. 19 (11): 7816–7827. doi:10.1128/mcb.19.11.7816. PMC 84849. PMID 10523670.
• Lu J, McKinsey TA, Nicol RL, Olson EN (Apr 2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases". Proceedings of the National Academy of Sciences of the United States of America. 97 (8): 4070–4075. Bibcode:2000PNAS...97.4070L. doi:10.1073/pnas.080064097. PMC 18151. PMID 10737771.
• Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD (Jun 2000). "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family". The Journal of Biological Chemistry. 275 (24): 18534–18540. doi:10.1074/jbc.M001573200. PMID 10849446.
• Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–4331. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.
• Slepak TI, Webster KA, Zang J, Prentice H, O'Dowd A, Hicks MN, Bishopric NH (Mar 2001). "Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D". The Journal of Biological Chemistry. 276 (10): 7575–7585. doi:10.1074/jbc.M004625200. PMID 11096067.
• Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research. 29 (13): 2836–2842. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030.
• Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA (Mar 2002). "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 99 (6): 3974–3979. Bibcode:2002PNAS...99.3974O. doi:10.1073/pnas.022036399. PMC 122633. PMID 11904443.
• Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/S0161-5890(02)00055-X. PMID 12213324.
• Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA (Oct 2003). "Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival". The Journal of Biological Chemistry. 278 (42): 41472–41481. doi:10.1074/jbc.M307245200. PMID 12896970.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Grégoire S, Yang XJ (Mar 2005). "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors". Molecular and Cellular Biology. 25 (6): 2273–2287. doi:10.1128/MCB.25.6.2273-2287.2005. PMC 1061617. PMID 15743823.
• Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP (May 2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia". Leukemia. 19 (5): 806–813. doi:10.1038/sj.leu.2403684. PMID 15744350.

External links

• MEF2D+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)