Octamer transcription factor

Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence.[1] Their DNA-binding domain is a POU domain.

There are eight Octamer proteins in humans (Oct1–11),[2] which have been renamed according to the different classes of POU domain.[3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells.[3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues.[3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development.[3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.[3]

Human Oct proteins

See also: Human POU domain proteins

References

  1. ^ Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB (1990). "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1099–103. Bibcode:1990PNAS...87.1099P. doi:10.1073/pnas.87.3.1099. PMC 53418. PMID 1967834.
  2. ^ Oct-5 and Oct-10 are not found in humans, while Oct-3 and Oct-4 were identified as the same protein.
  3. ^ a b c d e Zhao, FQ (1 June 2013). "Octamer-binding transcription factors: genomics and functions". Frontiers in Bioscience (Landmark Edition). 18 (3): 1051–71. doi:10.2741/4162. PMC 4349413. PMID 23747866.

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