POU2F3

POU2F3
Identifiers
Aliases	POU2F3, Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a, POU class 2 homeobox 3
External IDs	OMIM: 607394; MGI: 102565; HomoloGene: 7898; GeneCards: POU2F3; OMA:POU2F3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 120,236,640 bp[1] End 120,319,945 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.1|9 24.21 cM Start 43,035,234 bp[2] End 43,121,666 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg skin of thigh skin of hip nipple skin of arm vulva palpebral conjunctiva human penis mucosa of transverse colon Top expressed in lip gastrula Ileal epithelium urethra zygote male urethra zone of skin skin of external ear skin of back embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription by RNA polymerase II epidermis development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25833 18988 Ensembl ENSG00000137709 ENSMUSG00000032015 UniProt Q9UKI9 P31362 RefSeq (mRNA) NM_001244682 NM_014352 NM_011139 RefSeq (protein) NP_001231611 NP_055167 n/a Location (UCSC) Chr 11: 120.24 – 120.32 Mb Chr 9: 43.04 – 43.12 Mb PubMed search [3] [4]
Wikidata
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POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.^[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000137709 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032015 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (Oct 1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor". J Biol Chem. 274 (37): 26399–406. doi:10.1074/jbc.274.37.26399. PMID 10473598.
6. "Entrez Gene: POU2F3 POU domain, class 2, transcription factor 3".

Further reading

• Goldsborough A, et al. (1990). "Cloning and sequencing of POU-boxes expressed in mouse testis". Nucleic Acids Res. 18 (6): 1634. doi:10.1093/nar/18.6.1634. PMC 330540. PMID 1970171.
• Goldsborough AS, Healy LE, Copeland NG, et al. (1993). "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11". Nucleic Acids Res. 21 (1): 127–34. doi:10.1093/nar/21.1.127. PMC 309074. PMID 8441607.
• Sugihara TM, Kudryavtseva EI, Kumar V, et al. (2001). "The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300". J. Biol. Chem. 276 (35): 33036–44. doi:10.1074/jbc.M103000200. PMID 11429405.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. hdl:1887/50054. PMID 12624109.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Enomoto Y, Enomoto K, Kitamura T, Kanda T (2004). "Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines". Oncogene. 23 (29): 5014–22. doi:10.1038/sj.onc.1207653. PMID 15077167.
• Jiménez-Mateo O, Rodríguez-Torres A, Avila S, Castrillo JL (2006). "The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression". Placenta. 27 (4–5): 357–66. doi:10.1016/j.placenta.2005.03.011. PMID 16005513.
• Zhang Z, Huettner PC, Nguyen L, et al. (2006). "Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer". Oncogene. 25 (39): 5436–45. doi:10.1038/sj.onc.1209530. PMID 16607278.
• Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.