V-erbA-related gene

NR2F6
Identifiers
Aliases	NR2F6, EAR-2, EAR2, ERBAL2, nuclear receptor subfamily 2 group F member 6
External IDs	OMIM: 132880; MGI: 1352453; HomoloGene: 7706; GeneCards: NR2F6; OMA:NR2F6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,231,883 bp[1] End 17,245,919 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.43 cM Start 71,826,767 bp[2] End 71,834,604 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of transverse colon nasal epithelium jejunal mucosa palpebral conjunctiva right lobe of liver mucosa of sigmoid colon apex of heart corpus epididymis olfactory zone of nasal mucosa Top expressed in right kidney Paneth cell proximal tubule left lobe of liver internal carotid artery external carotid artery choroid plexus of fourth ventricle cumulus cell somite transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding nuclear receptor activity DNA-binding transcription factor activity DNA binding protein binding steroid hormone receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process transcription, DNA-templated signal transduction detection of temperature stimulus involved in sensory perception of pain entrainment of circadian clock by photoperiod negative regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter neuron development regulation of transcription, DNA-templated intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2063 13864 Ensembl ENSG00000160113 ENSMUSG00000002393 UniProt P10588 P43136 RefSeq (mRNA) NM_005234 NM_010150 RefSeq (protein) NP_005225 NP_005225.2 NP_034280 Location (UCSC) Chr 19: 17.23 – 17.25 Mb Chr 8: 71.83 – 71.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene.^[5] V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after its similarity to v-erbA (P03373), a helper of an oncoprotein called v-erbB in avian erythroblastosis virus.^[6]

Function

Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.^[7][8]

Interactions

V-erbA-related gene has been shown to interact with:

• COUP-TFII^[9]
• Thyroid hormone receptor beta^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000160113 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002393 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, et al. (December 1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Research. 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMC 338996. PMID 2905047.
6. Thormeyer D, Baniahmad A (October 1999). "The v-erbA oncogene (review)". International Journal of Molecular Medicine. 4 (4): 351–358. PMID 10493974.
7. Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, et al. (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Molecular and Cellular Biology. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182.
8. Liu X, Huang X, Sigmund CD (May 2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription". Circulation Research. 92 (9): 1033–40. doi:10.1161/01.RES.0000071355.82009.43. PMID 12690040.
9. Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, et al. (May 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The Journal of Biological Chemistry. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.

Further reading

• Bähler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (July 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics. 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.
• Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, et al. (May 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The Journal of Biological Chemistry. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
• Zhang Y, Dufau ML (January 2000). "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor". The Journal of Biological Chemistry. 275 (4): 2763–70. doi:10.1074/jbc.275.4.2763. PMID 10644740.
• Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, et al. (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Molecular and Cellular Biology. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182.
• Liu X, Huang X, Sigmund CD (May 2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription". Circulation Research. 92 (9): 1033–40. doi:10.1161/01.RES.0000071355.82009.43. PMID 12690040.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

External links

• NR2F6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)