HMGB4

HMGB4
Identifiers
Aliases	HMGB4, dJ1007G16.5, high mobility group box 4
External IDs	OMIM: 617285; MGI: 1916567; HomoloGene: 83321; GeneCards: HMGB4; OMA:HMGB4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.1 Start 33,860,475 bp[1] End 33,864,791 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 128,154,005 bp[2] End 128,154,750 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis sperm testicle tail of epididymis right coronary artery caput epididymis ectocervix right uterine tube canal of the cervix Top expressed in seminiferous tubule spermatid spermatocyte muscle tissue central gray substance of midbrain striated muscle tissue pancreas skeletal muscle tissue islet of Langerhans Hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding DNA binding transcription factor binding DNA binding, bending Cellular component nucleus chromosome cytoplasm Biological process activation of innate immune response DNA recombination chromatin remodeling regulation of transcription by RNA polymerase II regulation of signaling receptor activity positive regulation of autophagy developmental process positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of innate immune response positive regulation of transcription by RNA polymerase II cell chemotaxis positive regulation of ERK1 and ERK2 cascade positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127540 69317 Ensembl ENSG00000176256 ENSMUSG00000048686 UniProt Q8WW32 Q6P8W9 RefSeq (mRNA) NM_145205 NM_001352984 NM_001379301 NM_027036 RefSeq (protein) NP_660206 NP_001339913 NP_001366230 NP_081312 Location (UCSC) Chr 1: 33.86 – 33.86 Mb Chr 4: 128.15 – 128.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

High mobility group protein B4 is a transcription factor that in humans is encoded by the HMGB4 gene.^[5]

See also

• High-mobility group

References

1. GRCh38: Ensembl release 89: ENSG00000176256 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048686 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: high-mobility group box 4".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sogayar MC, Camargo AA, Bettoni F, et al. (2004). "A transcript finishing initiative for closing gaps in the human transcriptome". Genome Res. 14 (7): 1413–23. doi:10.1101/gr.2111304. PMC 442158. PMID 15197164.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.