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Lobelin
IUPAC ime
	2-((2R,6S)-6-((S)-2-Hidroksi-2-feniletil)-1-metilpiperidin-2-il)-1-feniletanon
Klinički podaci
Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	90-69-7
ATCvet kod	QV04CV01 (WHO)
PubChem	CID 101616
ChemSpider	91814
UNII	D0P25S3P81
KEGG	D02364
ChEMBL	CHEMBL15476
Hemijski podaci
Formula	C22H27NO2
Molarna masa	337,455
	SMILES O=C(c1ccccc1)C[C@@H]3N(C)[C@H](C[C@H](O)c2ccccc2)CCC3; ;
	InChI InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m0/s1 ; Key:MXYUKLILVYORSK-HBMCJLEFSA-N ;

Lobelin je prirodni alkaloid prisutan u biljkama Lobelia inflata, Lobelia tupa, Lobelia cardinalis, Lobelia siphilitica, i Hippobroma longiflora. U svojoj čistoj formi on je beli amorfni prah koji je rastvoran u vodi.

Lobelin kao pomoćno sredstvo za potiskivanje želje za pušenjem,^[1]^[2]^[3] a moguće je da primenljiv i kod drugih tipova zavisnosti, kao što je adikcija na amfetamin,^[4]^[5] kokain^[6] ili alkohol.^[7]

Reference

^ Stead LF, Hughes JR (2012). „Lobeline for smoking cessation”. Cochrane Database Syst Rev. 2012 (2): CD000124. PMC 7043274 . PMID 22336780. doi:10.1002/14651858.CD000124.pub2.
^ Marlow, S. P.; Stoller, J. K. (2003). „Smoking cessation”. Respiratory Care. 48 (12): 1238—54; discussion 1254—6. PMID 14651764.
^ Buchhalter, A. R.; Fant, R. V.; Henningfield, J. E. (2008). „Novel pharmacological approaches for treating tobacco dependence and withdrawal: Current status”. Drugs. 68 (8): 1067—1088. PMID 18484799. S2CID 46875770. doi:10.2165/00003495-200868080-00005.
^ Neugebauer, Nichole M.; Harrod, Steven B.; Stairs, Dustin J.; Crooks, Peter A.; Dwoskin, Linda P.; Bardo, Michael T. (2007). „Lobelane decreases methamphetamine self-administration in rats”. European Journal of Pharmacology. 571 (1): 33—38. PMC 2104779 . PMID 17612524. doi:10.1016/j.ejphar.2007.06.003.
^ Eyerman, D. J.; Yamamoto, B. K. (2005). „Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum”. The Journal of Pharmacology and Experimental Therapeutics. 312 (1): 160—169. PMID 15331654. S2CID 19787823. doi:10.1124/jpet.104.072264.
^ Polston, J. E.; Cunningham, C. S.; Rodvelt, K. R.; Miller, D. K. (2006). „Lobeline augments and inhibits cocaine-induced hyperactivity in rats”. Life Sciences. 79 (10): 981—990. PMID 16765386. doi:10.1016/j.lfs.2006.05.006.
^ Farook, J. M.; Lewis, B.; Gaddis, J. G.; Littleton, J. M.; Barron, S. (2009). „Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice”. Physiology & Behavior. 97 (3–4): 503—506. PMID 19268674. S2CID 23762679. doi:10.1016/j.physbeh.2009.02.031.

[1] Stead LF, Hughes JR (2012). „Lobeline for smoking cessation”. Cochrane Database Syst Rev. 2012 (2): CD000124. PMC 7043274 . PMID 22336780. doi:10.1002/14651858.CD000124.pub2.

[2] Marlow, S. P.; Stoller, J. K. (2003). „Smoking cessation”. Respiratory Care. 48 (12): 1238—54; discussion 1254—6. PMID 14651764.

[3] Buchhalter, A. R.; Fant, R. V.; Henningfield, J. E. (2008). „Novel pharmacological approaches for treating tobacco dependence and withdrawal: Current status”. Drugs. 68 (8): 1067—1088. PMID 18484799. S2CID 46875770. doi:10.2165/00003495-200868080-00005.

[4] Neugebauer, Nichole M.; Harrod, Steven B.; Stairs, Dustin J.; Crooks, Peter A.; Dwoskin, Linda P.; Bardo, Michael T. (2007). „Lobelane decreases methamphetamine self-administration in rats”. European Journal of Pharmacology. 571 (1): 33—38. PMC 2104779 . PMID 17612524. doi:10.1016/j.ejphar.2007.06.003.

[5] Eyerman, D. J.; Yamamoto, B. K. (2005). „Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum”. The Journal of Pharmacology and Experimental Therapeutics. 312 (1): 160—169. PMID 15331654. S2CID 19787823. doi:10.1124/jpet.104.072264.

[6] Polston, J. E.; Cunningham, C. S.; Rodvelt, K. R.; Miller, D. K. (2006). „Lobeline augments and inhibits cocaine-induced hyperactivity in rats”. Life Sciences. 79 (10): 981—990. PMID 16765386. doi:10.1016/j.lfs.2006.05.006.

[7] Farook, J. M.; Lewis, B.; Gaddis, J. G.; Littleton, J. M.; Barron, S. (2009). „Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice”. Physiology & Behavior. 97 (3–4): 503—506. PMID 19268674. S2CID 23762679. doi:10.1016/j.physbeh.2009.02.031.

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