Rilmenidin

Rilmenidin
(IUPAC) ime
N-(diciklopropilmetil)-4,5-dihidro-1,3-oksazol-2-amin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 54187-04-1
ATC kod C02AC06
PubChem[1][2] 68712
ChemSpider[3] 61963
UNII P67IM25ID8 DaY
ChEMBL[4] CHEMBL289480 DaY
Hemijski podaci
Formula C10H16N2O 
Mol. masa 180,247 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Vezivanje za proteine plazme 7%
Metabolizam Minimalan
Poluvreme eliminacije 8 sata
Izlučivanje Renalno, nepromenjen
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno

Rilmenidin je lek koji se koristi za treatiranje hipertenzije.[5] On je u prodaji pod imenima Hyperium i Tenaxum.

Tableta

Svaka tableta sadrži 1,544 mg rilmenidin dihidrogen fosfata, količinu ekvuivalentnu sa 1,000 mg slobodne baze rilmenidina.

Način dejstva

Rilmenidin je oksazolinsko jedinjenje sa antihipertenzivnim svojstvima. On deluje na medularne i periferno vazomotorne strukture. Rilmenidin ima veću selektivnost za imidazolinske receptore nego za cerebralne alfa2-adrenergičke receptore, po čemu se razlikuje od referentnih alfa-2 agonista.

Reference

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Remková A, Kratochvíl'ová H (August 2002). „Effect of the new centrally acting antihypertensive agent rilmenidine on endothelial and platelet function in essential hypertension”. J Hum Hypertens 16 (8): 549–55. DOI:10.1038/sj.jhh.1001427. PMID 12149660. 

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