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Buflomedil
	4-(pirolidin-1-il)-1-(2,4,6-trimetoksifenil)butan-1-on
Identifikacija
CAS registarski broj	55837-25-7
PubChem	2467
ChemSpider	2373
ChEMBL	CHEMBL188921
ATC code	C04AX20
Jmol-3D slike	Slika 1
SMILES
	O=C(c1c(OC)cc(OC)cc1OC)CCCN2CCCC2
InChI
	InChI=1S/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3 ; Kod: OWYLAEYXIQKAOL-UHFFFAOYSA-N InChI=1/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3; Kod: OWYLAEYXIQKAOL-UHFFFAOYAG
Svojstva
Molekulska formula	C17H25NO4
Molarna masa	307,38 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Buflomedil je vazoaktivni lek koji se koristi za tretiranje klaudikacije ili simptoma periferne arterijske bolesti. On je dostupan u obliku tableta pod imenom Loftyl.

Toksičnost

Moguće je da će ovaj lek biti suspendovan iz prodaje u Evropskoj Uniji, jer potencijalno može da proizvede ozbiljnu neurološku i srčanu toksičnost.^[5]^[6]

Niz nepoželjnih efekata je objavljen u FDA izveštaju.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Medscape
↑ „European Medicines Agency recommends suspension of all buflomedil-containing medicines”. Arhivirano iz originala na datum 2012-01-23. Pristupljeno 2014-04-12.
↑ Buflomedil Adverse Events Reported to the FDA Over Time

Vanjske veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Medscape

[6] „European Medicines Agency recommends suspension of all buflomedil-containing medicines”. Arhivirano iz originala na datum 2012-01-23. Pristupljeno 2014-04-12.

[7] Buflomedil Adverse Events Reported to the FDA Over Time

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