Beta-galaktozid transacetilaza

GAT u kompleksu sa KoA i dva molekula/aktivna mesta IPTG

β-galaktozid transacetilaza je enzim koji vrši transfer acetil grupe sa acetil-KoA na β-galaktozide. Kodiran je genom (lacA) u lac operonu bakterije Escherichia coli.^[1] Precisza funkcija ovog enzima u okviru lac operona trenutno nije poznata.^[2] Njegova kinetika je razjašnjena 1995.^[3]

Povezano

• Acetiltransferaza

Reference

1. Wang XG; Olsen LR; Roderick SL. (April 2002). „Structure of the lac operon galactoside acetyltransferase”. Structure 10 (4): 581–8. DOI:10.1016/S0969-2126(02)00741-4. PMID 11937062. 
2. Roderick SL. (June 2005). „The lac operon galactoside acetyltransferase”. C R Biol. 328 (6): 568–75. DOI:10.1016/j.crvi.2005.03.005. PMID 15950163. 
3. A. Lewendon; J. Ellis, W.V. Shaw (1995). „Structural and Mechanistic Studies of Galactoside Acetyltransferase, the Escherichia coli LacA Gene Product”. J. Biol. Chem. 270 (44): 26326–31.. DOI:10.1074/jbc.270.44.26326. PMID 7592843. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH galactoside+acetyltransferase
• EC 2.3.1.18