Acetil-KoA C-aciltransferaza

Acetil-KoA C-aciltransferaza
Identifikatori
EC broj	2.3.1.16
CAS broj	9029-97-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Acetil-KoA C-aciltransferaza (EC 2.3.1.16, beta-ketotiolaza, 3-ketoacil-KoA tiolaza, KAT, beta-ketoacil koenzim A tiolaza, beta-ketoacil-KoA tiolaza, beta-ketoadipil koenzim A tiolaza, beta-ketoadipil-KoA tiolaza, 3-ketoacil KoA tiolaza, 3-ketoacil koenzim A tiolaza, 3-ketoacilna tiolaza, 3-ketotiolaza, 3-oksoacil-KoA tiolaza, 3-oksoacil-koenzim A tiolaza, 6-oksoacil-KoA tiolaza, acetoacetil-KoA beta-ketotiolaza, acetil-KoA aciltransferaza, ketoacil-KoA aciltransferaza, ketoacil-koenzim A tiolaza, dugolančana 3-oksoacil-KoA tiolaza, oksoacil-koenzim A tiolaza, pro-3-ketoacil-KoA tiolaza, tiolaza I, 2-metilacetoacetil-KoA tiolaza) je enzim sa sistematskim imenom acil-KoA:acetil-KoA C-aciltransferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

acil-KoA + acetil-KoA ${\displaystyle \rightleftharpoons }$ KoA + 3-oksoacil-KoA

Reference

1. Beinert, H., Bock, R.M., Goldman, D.S., Green, D.E., Mahler, H.R., Mii, S., Stansly, P.G. and Wakil, S.J. (1953). „A synthesis of dl-cortisone acetate”. J. Am. Chem. Soc. 75: 4111-4112. 
2. Goldman, D.S. (1954). „Studies on the fatty acid oxidizing system of animal tissue. VII. The β-ketoacyl coenzyme A cleavage enzyme”. J. Biol. Chem. 208: 345-357. PMID 13174544. 
3. Stern, J.R., Coon, M.J. and del Campillo, A. (1953). „Enzymatic breakdown and synthesis of acetoacetate”. Nature 171: 28-30. PMID 13025466. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Acetyl-CoA+C-acyltransferase