1-Acilglicerofosfoholin O-aciltransferaza

1-Acilglicerofosfoholin O-aciltransferaza
Identifikatori
EC broj	2.3.1.23
CAS broj	9027-64-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

1-Acilglicerofosfoholin O-aciltransferaza (EC 2.3.1.23, lizolecitinska aciltransferaza, 1-acil-sn-glicero-3-fosfoholinska aciltransferaza, acil koenzim A-monoacilfosfatidilholinska aciltransferaza, acil-KoA:1-acil-glicero-3-fosfoholinska transacilaza, lizofosfatidna aciltransferaza, lizofosfatidilholinska aciltransferaza) je enzim sa sistematskim imenom acil-KoA:1-acil-sn-glicero-3-fosfoholin O-aciltransferaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

acil-KoA + 1-acil-sn-glicero-3-fosfoholin ${\displaystyle \rightleftharpoons }$ KoA + 1,2-diacil-sn-glicero-3-fosfoholin

Ovaj enzim preferentno deluje na nezasićene acil-KoA derivate. 1-acil-sn-glicero-3-fosfoinozitol takođe mođe da bude akceptor.

Reference

1. Bell, R.M. and Coleman, R.A. (1980). „Enzymes of glycerolipid synthesis in eukaryotes”. Annu. Rev. Biochem. 49: 459-487. PMID 6250446. 
2. Hill, E.E. and Lands, W.E.M. (1968). „Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine”. Biochim. Biophys. Acta 152: 645-648. PMID 5661029. 
3. Miki, Y., Hosaka, K., Yamashita, S., Handa, H. and Numa, S. (1977). „Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes”. Eur. J. Biochem. 81: 433-441. PMID 598375. 
4. van den Bosch, H., van Golde, L.M.G., Eibl, H. and van Deenen, L.L.M. (1967). „The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes”. Biochim. Biophys. Acta 144: 613-623. PMID 6078124. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 1-acylglycerophosphocholine+O-acyltransferase