己二烯雌酚
己二烯雌酚 | 臨床資料 |
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商品名 | Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Cycladiene, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol |
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其他名稱 | Dienoestrol; p-[(E,E)-1-Ethylidene-2-(p-hydroxyphenyl)-2-butenyl]phenol; 3,4-Di(para-hydroxyphenyl)-2,4-hexadiene |
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AHFS/Drugs.com | Micromedex详细消费者药物信息 |
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藥物類別 | Nonsteroidal estrogen |
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ATC碼 | |
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识别信息 |
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4-[4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol
| CAS号 | 13029-44-2 N |
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PubChem CID | |
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IUPHAR/BPS | |
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DrugBank | |
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ChemSpider | |
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UNII | |
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KEGG | |
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ChEBI | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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ECHA InfoCard | 100.001.381 |
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化学信息 |
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化学式 | C18H18O2 |
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摩尔质量 | 266.34 g·mol−1 |
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3D模型(JSmol) | |
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Oc2ccc(C(/C(c1ccc(O)cc1)=C/C)=C\C)cc2
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InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+ YKey:NFDFQCUYFHCNBW-SCGPFSFSSA-N Y
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己二烯雌酚(英語:Dienestrol)是一种非甾体雌激素,是乙烯雌酚衍生物,比己烯雌酚多一个不饱和度,在美国和欧盟用作治疗更年期综合征的药物[1][2][3][4]。也有研究将其用作男性前列腺癌的直肠给药药物[5]。
参考文献
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| 雌激素 | ER(雌激素受體) 激動劑 |
- (甾體類) Alfatradiol
- 某些雄激素/合成类固醇(e.g., testosterone, testosterone esters, methyltestosterone, metandienone, nandrolone esters) (via estrogenic metabolites)
- 某些黃體製劑 (例如:諾瑞酮,左炔诺孕酮二醋酸酯,替前列酮)
- 氯米酮
- 醋酸邻雌二醇
- 共轭雌三醇
- 共轭雌激素
- 环雌三醇
- 环雌甲酮
- 酯化雌激素
- 雌四醇†
- 雌二醇
- Estradiol esters (e.g., estradiol acetate, estradiol benzoate, estradiol cypionate, estradiol enanthate, estradiol undecylate, estradiol valerate, polyestradiol phosphate, estradiol ester mixtures (Climacteron))
- Estramustine phosphate
- Estriol
- Estriol esters (e.g., estriol succinate, polyestriol phosphate)
- Estrogenic substances
- Estrone
- Estrone esters
- * Estrone sulfate
- * Estropipate (piperazine estrone sulfate)
- Ethinylestradiol#
- * Ethinylestradiol sulfonate
- Hydroxyestrone diacetate
- Mestranol
- Methylestradiol
- Moxestrol
- Nilestriol
- Prasterone (dehydroepiandrosterone; DHEA)
- Prasterone enanthate
- Prasterone sulfate
- Promestriene
- Quinestradol
- Quinestrol
- (非甾體類) Benzestrol
- Bifluranol
- Chlorotrianisene
- Dienestrol
- 双乙酸双烯雌酚
- 乙烯雌酚(己烯雌酚(stilbestrol))
- Diethylstilbestrol esters/ethers
- Dimestrol (diethylstilbestrol dimethyl ether)
- Fosfestrol (diethylstilbestrol diphosphate)
- Mestilbol (diethylstilbestrol monomethyl ether)
- Doisynoestrol (fenocycline)
- Hexestrol
- Hexestrol esters
- Methallenestril
- Methestrol (promethestrol)
- Methestrol dipropionate (promethestrol dipropionate)
- Paroxypropione
- Quadrosilan
- Triphenylbromoethylene
- Triphenylchloroethylene
- Zeranol
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| 促性腺激素 | |
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| 抗雌激素 | ER拮抗剂 (包含SERMs/SERDs) | |
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| 芳香酶抑制剂 | |
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| 抗性腺激素 |
- 雄激素/合成類固酮 (例如 睪酮, 睪酮酯, nandrolone esters, oxandrolone, 氟氧孕酮)
- D2 receptor antagonists (prolactin releasers) (e.g., domperidone, metoclopramide, risperidone, haloperidol, chlorpromazine, sulpiride)
- GnRH agonists (e.g., leuprorelin, goserelin)
- GnRH antagonists (e.g., cetrorelix, elagolix)
- Progestogens (e.g., chlormadinone acetate, cyproterone acetate, gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate)
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