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胆固醇侧链裂解酶
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3NA1、3N9Y、3N9Z、3NA0
識別號
别名	CYP11A1；, CYP11A, CYPXIA1, P450SCC, cytochrome P450 family 11 subfamily A member 1
外部ID	OMIM：118485 MGI：88582 HomoloGene：37347 GeneCards：CYP11A1
相關疾病
	congenital adrenal insufficiency
為以下藥物的標靶
	米托坦、氨鲁米特
基因位置（人类）
染色体	15號染色體
终止	74,367,646 bp
基因位置（小鼠）
染色体	小鼠9号染色体
终止	57,934,306 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• iron ion binding; • 金屬離子結合; • monooxygenase activity; • heme binding; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • cholesterol monooxygenase (side-chain-cleaving) activity; • 血浆蛋白结合;
細胞組分	• 膜; • 线粒体基质; • 線粒體; • mitochondrial inner membrane;
生物學過程	• vitamin D metabolic process; • C21-steroid hormone metabolic process; • 脂質代謝; • cholesterol metabolic process; • C21-steroid hormone biosynthetic process; • sterol metabolic process; • steroid biosynthetic process; • steroid metabolic process; • glucocorticoid biosynthetic process; • cellular response to peptide hormone stimulus; • cortisol metabolic process;
	Sources:Amigo / QuickGO
直系同源
	1583
	13070
	ENSG00000140459; ENSG00000288362
	ENSMUSG00000032323
	P05108
	Q9QZ82
	NM_001099773; NM_000781
	NM_019779; NM_001346787
	NP_000772; NP_001093243
	NP_001333716; NP_062753
	維基數據
檢視/編輯人類	檢視/編輯小鼠

胆固醇侧链裂解酶（英語：Cholesterol side-chain cleavage enzyme，CYP11A1或P450scc，其中“scc”是“side-chain 侧链”“cleavage 裂解”的缩写）是一种将胆固醇转化为孕烯醇酮的线粒体酶。这是所有哺乳动物中由胆固醇生成各种甾类激素的第一步反应^[7]。

胆固醇 + 3 NADPH + 3 H⁺ + 3 O₂ ⇄ 孕烯醇酮 + 4-甲基戊醛 + 3 NADP⁺ + 3 H₂O

P450scc 是细胞色素P450氧化酶超家族的一员（家族11亚家族A多肽1），基因名为 CYP11A1^[8]。

另见

参考文献

^ 與胆固醇侧链裂解酶相關的疾病；在維基數據上查看/編輯參考.
^ 對胆固醇侧链裂解酶起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000140459、ENSG00000288362 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000032323 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology. December 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5.
^ Entrez Gene: CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1.

延伸阅读

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