Filgrastim

Filgrastim
Nama sistematis (IUPAC)
faktor stimulasi koloni granulosit
Data klinis
Nama dagang Neupogen
AHFS/Drugs.com monograph
Kat. kehamilan ?
Status hukum ?
Pengenal
Nomor CAS 143011-72-7
Kode ATC L03AA02
Ligan IUPHAR 6968
DrugBank DB00099
ChemSpider none
UNII PVI5M0M1GW YaY
ChEMBL CHEMBL1201567
Data kimia
Rumus C845H1343N223O243S9 
Massa mol. 18802.8 g/mol

Filgrastim adalah analog faktor stimulasi koloni granulosit (G-CSF) yang digunakan untuk merangsang proliferasi dan diferensiasi granulosit;[1] ini adalah farmasi analog dari G-CSF alami. Obat ini dihasilkan dengan teknologi DNA rekombinan. Gen untuk faktor stimulasi koloni granulosit manusia dimasukkan ke dalam materi genetik Escherichia coli. G-CSF yang dihasilkan oleh E. coli berbeda dari G-CSF alami yang dibuat manusia.

Filgrastim dilisensi pertama kali oleh Amgen pada tahun 1991.[2] Obat ini termasuk dalam Daftar Obat Esensial Organisasi Kesehatan Dunia, daftar obat-obatan paling penting yang dibutuhkan pada sistem kesehatan dasar.[3] Pada tahun 2015 filgrastim menjadi obat pertama yang memiliki biosimilar yang disetujui oleh FDA Amerika Serikat; bahwa Nama Generik Internasional biosimilarnya adalah filgrastim-sndz.

Penggunaan medis

Filgrastim digunakan untuk mengobati neutropenia,[4] merangsang sumsum tulang untuk meningkatkan produksi neutrofil. Penyebab neutropenia termasuk kemoterapi dan transplantasi sumsum tulang.

Perusahaan Merek
Cadila Pharmaceuticals Filcad
Abbott Laboratories Imumax
Dr. Reddy's Laboratories Grafeel
Intas Biopharmaceuticals Neukine
Amgen Neupogen[5]
Emcure Pharmaceuticals Emgrast
Reliance Life Sciences Religrast
Novartis Zarzio atau Zarxio, produk biosimilar [2]
Biocon Nufil

Referensi

  1. ^ Beveridge, R. A.; Miller, J. A.; Kales, A. N.; Binder, R. A.; Robert, N. J.; Harvey, J. H.; Windsor, K.; Gore, I.; Cantrell, J. (1998). "A Comparison of Efficacy of Sargramostim (Yeast-Derived RhuGM-CSF) and Filgrastim (Bacteria-Derived RhuG-CSF) in the Therapeutic Setting of Chemotherapy-Induced Myelosuppression". Cancer Investigation. 16 (6): 366–373. doi:10.3109/07357909809115775. PMID 9679526. 
  2. ^ a b "FDA approves first biosimilar product Zarxio", FDA, March 6, 2015, diarsipkan dari versi asli tanggal 2018-01-26, diakses tanggal 23 November 2015 
  3. ^ "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Diarsipkan (PDF) dari versi asli tanggal 2015-05-13. Diakses tanggal May 10, 2015. 
  4. ^ Crawford, J.; Glaspy, J. A.; Stoller, R. G.; Tomita, D. K.; Vincent, M. E.; McGuire, B. W.; Ozer, H. (2005). "Final Results of a Placebo-Controlled Study of Filgrastim in Small-Cell Lung Cancer: Exploration of Risk Factors for Febrile Neutropenia". Supportive Cancer Therapy. 3 (1): 36–46. doi:10.3816/SCT.2005.n.023. PMID 18632435. 
  5. ^ "FDA Reviews What Could Be First Biosimilar". Discov. Dev. Mag. Rockaway, New Jersey, United States. Associated Press. 25 July 2014. Diarsipkan dari versi asli tanggal 2014-07-29. Diakses tanggal 2016-09-22. 

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