SIRPG

SIRPG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JJW, 4I2X
Identifiers
Aliases	SIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDs	OMIM: 605466; MGI: 108563; HomoloGene: 56809; GeneCards: SIRPG; OMA:SIRPG - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 1,629,152 bp[1] End 1,657,779 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.19 cM Start 129,434,755 bp[2] End 129,474,148 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus testicle lymph node granulocyte blood appendix spleen mucosa of transverse colon left testis right testis Top expressed in stroma of bone marrow granulocyte prefrontal cortex superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex tibiofemoral joint perirhinal cortex entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane intracellular anatomical structure Biological process cell-cell signaling cell adhesion intracellular signal transduction positive regulation of T cell activation leukocyte migration positive regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55423 19261 Ensembl ENSG00000089012 ENSMUSG00000037902 UniProt Q9P1W8 P97797 RefSeq (mRNA) NM_001039508 NM_018556 NM_080816 NM_001177646 NM_001177647 NM_001291019 NM_001291020 NM_001291021 NM_001291022 NM_007547 NM_001355158 NM_001355160 RefSeq (protein) NP_001034597 NP_061026 NP_543006 NP_001171118 NP_001277948 NP_001277949 NP_001277950 NP_001277951 NP_031573 NP_001342087 NP_001342089 Location (UCSC) Chr 20: 1.63 – 1.66 Mb Chr 2: 129.43 – 129.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.^[5][6][7] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000089012 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037902 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001). "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family". J Hum Genet. 45 (6): 378–82. doi:10.1007/s100380070013. PMID 11185750.
6. van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.
7. "Entrez Gene: SIRPG signal-regulatory protein gamma".

Further reading

• Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID 9062191. S2CID 4259314.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brooke G, Holbrook JD, Brown MH, Barclay AN (2004). "Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family". J. Immunol. 173 (4): 2562–70. doi:10.4049/jimmunol.173.4.2562. PMID 15294972.
• Piccio L, Vermi W, Boles KS, et al. (2006). "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation". Blood. 105 (6): 2421–7. doi:10.1182/blood-2004-07-2823. PMID 15383453.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.