SIGLEC9

SIGLEC9
Identifiers
Aliases	SIGLEC9, CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9, sialic acid binding Ig like lectin 9
External IDs	OMIM: 605640; MGI: 1932475; HomoloGene: 130669; GeneCards: SIGLEC9; OMA:SIGLEC9 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,124,906 bp[1] End 51,136,651 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 Start 43,300,494 bp[2] End 43,309,585 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood spleen upper lobe of left lung gonad right adrenal cortex appendix right lung left adrenal gland Top expressed in granulocyte zygote secondary oocyte spleen blood embryo embryo right kidney bone marrow primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane secretory granule membrane Biological process cell surface receptor signaling pathway cell adhesion regulation of immune response neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27180 83382 Ensembl ENSG00000129450 ENSMUSG00000030474 UniProt Q9Y336 Q91Y57 RefSeq (mRNA) NM_001198558 NM_014441 NM_031181 RefSeq (protein) NP_001185487 NP_055256 NP_112458 Location (UCSC) Chr 19: 51.12 – 51.14 Mb Chr 7: 43.3 – 43.31 Mb PubMed search [3] [4]
Wikidata
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Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.^[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000129450 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030474 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Foussias G, Yousef GM, Diamandis EP (Aug 2000). "Identification and molecular characterization of a novel member of the siglec family (SIGLEC9)". Genomics. 67 (2): 171–8. doi:10.1006/geno.2000.6208. PMID 10903842.
6. "Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9".

Further reading

• Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Res. 19 (4B): 2843–52. PMID 10652563.
• Angata T, Varki A (2000). "Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways". J. Biol. Chem. 275 (29): 22127–35. doi:10.1074/jbc.M002775200. PMID 10801860.
• Zhang JQ, Nicoll G, Jones C, Crocker PR (2000). "Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes". J. Biol. Chem. 275 (29): 22121–6. doi:10.1074/jbc.M002788200. PMID 10801862.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Sonnenburg JL, Altheide TK, Varki A (2004). "A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor". Glycobiology. 14 (4): 339–46. doi:10.1093/glycob/cwh039. PMID 14693915.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Ikehara Y, Ikehara SK, Paulson JC (2004). "Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9". J. Biol. Chem. 279 (41): 43117–25. doi:10.1074/jbc.M403538200. PMID 15292262.
• Avril T, Floyd H, Lopez F, et al. (2005). "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells". J. Immunol. 173 (11): 6841–9. doi:10.4049/jimmunol.173.11.6841. PMID 15557178.
• von Gunten S, Yousefi S, Seitz M, et al. (2005). "Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment". Blood. 106 (4): 1423–31. doi:10.1182/blood-2004-10-4112. PMID 15827126.
• Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc. 71 (5): 496–504. doi:10.1134/S0006297906050051. PMID 16732727. S2CID 11537303.
• Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res. 31 (2): 211–20. doi:10.1016/j.leukres.2006.05.026. PMID 16828866.