CD96

CD96
Identifiers
Aliases	CD96, TACTILE, CD96 molecule
External IDs	OMIM: 606037; MGI: 1934368; HomoloGene: 68489; GeneCards: CD96; OMA:CD96 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.13-q13.2 Start 111,292,719 bp[1] End 111,665,750 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 45,856,020 bp[2] End 45,940,614 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node blood spleen appendix epithelium of colon gallbladder rectum mucosa of transverse colon bone marrow cells Top expressed in thymus seminiferous tubule blood mesenteric lymph nodes ganglion of vagus nerve pharynx spleen subcutaneous adipose tissue secondary oocyte jejunum More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10225 84544 Ensembl ENSG00000153283 ENSMUSG00000022657 UniProt P40200 Q8WUE2 Q3U0X8 RefSeq (mRNA) NM_005816 NM_198196 NM_001318889 NM_032465 RefSeq (protein) NP_001305818 NP_005807 NP_937839 NP_001305818.1 NP_115854 Location (UCSC) Chr 3: 111.29 – 111.67 Mb Chr 16: 45.86 – 45.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For the isotope of cadmium (Cd-96 or ⁹⁶Cd), see Cadmium-96.

CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene.^[5] CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1).^[6] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation^{[citation needed]}. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.^[7]

Function

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000153283 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022657 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CD96 molecule". Retrieved 2018-07-03.
6. Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
7. Martinet L, Smyth MJ (April 2015). "Balancing natural killer cell activation through paired receptors". Nature Reviews. Immunology. 15 (4): 243–254. doi:10.1038/nri3799. PMID 25743219. S2CID 20825600.

Further reading

• Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M (April 2004). "Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)". Journal of Immunology. 172 (7): 3994–3998. doi:10.4049/jimmunol.172.7.3994. PMID 15034010.
• Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, et al. (June 2007). "CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia". Proceedings of the National Academy of Sciences of the United States of America. 104 (26): 11008–11013. Bibcode:2007PNAS..10411008H. doi:10.1073/pnas.0704271104. PMC 1904175. PMID 17576927.
• Kaname T, Yanagi K, Chinen Y, Makita Y, Okamoto N, Maehara H, et al. (October 2007). "Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome". American Journal of Human Genetics. 81 (4): 835–841. doi:10.1086/522014. PMC 2227933. PMID 17847009.
• Meyer D, Seth S, Albrecht J, Maier MK, du Pasquier L, Ravens I, et al. (January 2009). "CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains". The Journal of Biological Chemistry. 284 (4): 2235–2244. doi:10.1074/jbc.M807698200. PMID 19056733.
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, et al. (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity. 11 (3): 232–238. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
• Wu Y, Xiao M, Zhu L, Zhou XX, Gong Q, Xin X, et al. (June 2011). "[CD96 expression on bone marrow mononuclear cells in 91 patients with acute leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi (in Chinese). 19 (3): 585–588. PMID 21729528.
• Mohseni Nodehi S, Repp R, Kellner C, Bräutigam J, Staudinger M, Schub N, et al. (2012). "Enhanced ADCC activity of affinity maturated and Fc-engineered mini-antibodies directed against the AML stem cell antigen CD96". PLOS ONE. 7 (8): e42426. Bibcode:2012PLoSO...742426M. doi:10.1371/journal.pone.0042426. PMC 3411760. PMID 22879978.
• Eriksson EM, Keh CE, Deeks SG, Martin JN, Hecht FM, Nixon DF (2012). "Differential expression of CD96 surface molecule represents CD8⁺ T cells with dissimilar effector function during HIV-1 infection". PLOS ONE. 7 (12): e51696. Bibcode:2012PLoSO...751696E. doi:10.1371/journal.pone.0051696. PMC 3521672. PMID 23272144.
• Chávez-González A, Dorantes-Acosta E, Moreno-Lorenzana D, Alvarado-Moreno A, Arriaga-Pizano L, Mayani H (May 2014). "Expression of CD90, CD96, CD117, and CD123 on different hematopoietic cell populations from pediatric patients with acute myeloid leukemia". Archives of Medical Research. 45 (4): 343–350. doi:10.1016/j.arcmed.2014.04.001. PMID 24751333.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.