FCGR1A

FCGR1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4W4O, 4X4M, 4ZNE
Identifiers
Aliases	FCGR1A, CD64, CD64A, FCRI, IGFR1, Fc fragment of IgG receptor Ia
External IDs	OMIM: 146760; MGI: 95498; HomoloGene: 475; GeneCards: FCGR1A; OMA:FCGR1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,782,671 bp[1] End 149,792,518 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.1|3 41.72 cM Start 96,190,225 bp[2] End 96,201,285 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood placenta right coronary artery appendix C1 segment substantia nigra testicle bone marrow Top expressed in stroma of bone marrow lumbar subsegment of spinal cord calvaria interventricular septum spleen CA3 field embryo granulocyte dermis mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding IgG binding Cellular component integral component of membrane clathrin-coated endocytic vesicle membrane early endosome membrane membrane plasma membrane Biological process immune system process phagocytosis, engulfment antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent immune response Fc-gamma receptor signaling pathway involved in phagocytosis signal transduction regulation of immune response interferon-gamma-mediated signaling pathway receptor-mediated endocytosis innate immune response positive regulation of protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2209 14129 Ensembl ENSG00000150337 ENSMUSG00000015947 UniProt P12314 P26151 RefSeq (mRNA) NM_000566 NM_010186 RefSeq (protein) NP_000557 NP_001365733 NP_001365734 NP_001365735 NP_001365736 NP_001365737 NP_001365738 NP_001365739 NP_001365740 NP_034316 Location (UCSC) Chr 1: 149.78 – 149.79 Mb Chr 3: 96.19 – 96.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.^[5][6][7]

Interactions

The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000150337 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015947 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics. 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799.
6. Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics. 82 (1–2): 71–4. doi:10.1159/000015067. PMID 9763663. S2CID 20290009.
7. "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".
8. The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology

Further reading

• Monteiro RC, Van De Winkel JG (2003). "IgA Fc receptors". Annual Review of Immunology. 21: 177–204. doi:10.1146/annurev.immunol.21.120601.141011. PMID 12524384.
• Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (Aug 1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". The Journal of Biological Chemistry. 267 (22): 15692–700. doi:10.1016/S0021-9258(19)49591-4. PMID 1379234.
• Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA (Oct 1992). "Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure". The Journal of Experimental Medicine. 176 (4): 1115–23. doi:10.1084/jem.176.4.1115. PMC 2119393. PMID 1402657.
• Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP (Nov 1992). "Novel Fc gamma receptor I family gene products in human mononuclear cells". The Journal of Clinical Investigation. 90 (5): 2102–9. doi:10.1172/JCI116094. PMC 443278. PMID 1430234.
• van de Winkel JG, Ernst LK, Anderson CL, Chiu IM (Jul 1991). "Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene". The Journal of Biological Chemistry. 266 (20): 13449–55. doi:10.1016/S0021-9258(18)98860-5. PMID 1830050.
• Eizuru Y, Minamishima Y (1989). "Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts". Intervirology. 29 (6): 339–45. doi:10.1159/000150065. PMID 2852656.
• Allen JM, Seed B (Jan 1989). "Isolation and expression of functional high-affinity Fc receptor complementary DNAs". Science. 243 (4889): 378–81. Bibcode:1989Sci...243..378A. doi:10.1126/science.2911749. PMID 2911749.
• Allen JM, Seed B (Dec 1988). "Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI)". Nucleic Acids Research. 16 (24): 11824. doi:10.1093/nar/16.24.11824. PMC 339124. PMID 2974947.
• Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD (Jul 1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599–606. PMID 7516890.
• Valerius T, Repp R, de Wit TP, Berthold S, Platzer E, Kalden JR, Gramatzki M, van de Winkel JG (Aug 1993). "Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy". Blood. 82 (3): 931–9. doi:10.1182/blood.V82.3.931.931. PMID 7687898.
• Wang AV, Scholl PR, Geha RS (Sep 1994). "Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn". The Journal of Experimental Medicine. 180 (3): 1165–70. doi:10.1084/jem.180.3.1165. PMC 2191633. PMID 8064233.
• Takai S, Kasama M, Yamada K, Kai N, Hirayama N, Namiki H, Taniyama T (Jan 1994). "Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization". Human Genetics. 93 (1): 13–5. doi:10.1007/BF00218905. PMID 8270248. S2CID 24623391.
• Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370.
• De SK, Venkateshan CN, Seth P, Gajdusek DC, Gibbs CJ (Mar 1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood. 91 (6): 2108–17. doi:10.1182/blood.V91.6.2108. PMID 9490697.
• Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (Nov 1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)". Journal of Immunology. 161 (10): 5555–63. doi:10.4049/jimmunol.161.10.5555. PMID 9820532.
• Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
• Gorgani NN, Altin JG, Parish CR (Aug 1999). "Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes". International Immunology. 11 (8): 1275–82. doi:10.1093/intimm/11.8.1275. PMID 10421785.
• Tridandapani S, Lyden TW, Smith JL, Carter JE, Coggeshall KM, Anderson CL (Jul 2000). "The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells". The Journal of Biological Chemistry. 275 (27): 20480–7. doi:10.1074/jbc.M909462199. PMID 10781611.

External links

• Overview of all the structural information available in the PDB for UniProt: P12314 (Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A)) at the PDBe-KB.