Signal-regulatory protein

Signal-regulatory protein
Identifiers
Symbol	SRP
Membranome	42

A Signal-regulatory protein (SIRP) is one of a family of transmembrane glycoproteins involved in immunological signalling, expressed mainly by myeloid cells.^[1][2]

Members include :

• Signal-regulatory protein alpha, ligand=CD47^[1]
• SIRPB1
• SIRPB2^[3]
• SIRPD
• SIRPG, ligand=CD47^[1]

References

1. van Beek EM, Cochrane F, Barclay AN, van den Berg TK (December 2005). "Signal regulatory proteins in the immune system". Journal of Immunology. 175 (12): 7781–7. doi:10.4049/jimmunol.175.12.7781. PMID 16339510.
2. Barclay AN, Brown MH (June 2006). "The SIRP family of receptors and immune regulation". Nature Reviews. Immunology. 6 (6): 457–64. doi:10.1038/nri1859. PMID 16691243. S2CID 7915923.
3. Visser N, Nelemans LC, He Y, Lourens HJ, Corrales MG, Huls G, Wiersma VR, Schuringa JJ, Bremer E (December 2023). "Signal regulatory protein beta 2 is a novel positive regulator of innate anticancer immunity". Frontiers in Immunology. 14: 1287256. doi:10.3389/fimmu.2023.1287256. PMID 38116002.