Norgestomet

Not to be confused with norgestimate.
Norgestomet
Clinical data
Trade namesSyncro-Mate B, Crestar
Other namesNorgestamet; SC-21009; 11β-Methyl-17α-acetoxy-19-norprogesterone; 17α-Hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate
Drug classProgestogen; Progestin; Progestogen ester
Identifiers
  • [(8R,9S,10R,11S,13S,14S,17R)-17-acetyl-11,13-dimethyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.042.359 Edit this at Wikidata
Chemical and physical data
FormulaC23H32O4
Molar mass372.505 g·mol−1
3D model (JSmol)
  • CC1CC2(C(CCC2(C(=O)C)OC(=O)C)C3C1C4CCC(=O)C=C4CC3)C
  • InChI=1S/C23H32O4/c1-13-12-22(4)20(9-10-23(22,14(2)24)27-15(3)25)19-7-5-16-11-17(26)6-8-18(16)21(13)19/h11,13,18-21H,5-10,12H2,1-4H3/t13-,18-,19-,20-,21+,22-,23-/m0/s1
  • Key:IWSXBCZCPVUWHT-VIFKTUCRSA-N

Norgestomet, or norgestamet, sold under the brand name Syncro-Mate B and Crestar, is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle.[1][2]

Uses

Veterinary

Norgestomet is used in veterinary medicine.

Pharmacology

Pharmacodynamics

Norgestomet is a progestogen. In addition to the progesterone receptor, it possesses weak (micromolar) affinity for the glucocorticoid receptor.[3]

Chemistry

See also: List of progestogens, Progestogen ester, and List of progestogen esters

Norgestomet, also known as 11β-methyl-17α-acetoxy-19-norprogesterone or as 17α-hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate, is a synthetic norpregnane steroid and a derivative of progesterone.[1][4]

History

Norgestomet was developed and introduced for veterinary use in the mid-1970s.[5]

Society and culture

Generic names

Norgestomet is the generic name of the drug and its INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, and BANTooltip British Approved Name.[1][4] It also known as norgestamet and is known by its developmental code name SC-21009.[1][4][6]

Brand names

Norgestomet is marketed under the brand names Syncro-Mate B and Crestar.[1][4]

References

  1. ^ a b c d e Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 887–. ISBN 978-1-4757-2085-3.
  2. ^ Favero RJ, Henderson EA, Kesler DJ (1 July 1990). "The Ability of Norgesomet Impregnated Poly(dimethylsiloxane) to Maintain Pregnancy Subsequent to Ovarietomy". In Gebelein CG, Dunn RL (eds.). Progress in Biomedical Polymers. Springer Science & Business Media. pp. 356–. ISBN 978-0-306-43523-2.
  3. ^ Moffatt RJ, Zollers WG, Welshons WV, Kieborz KR, Garverick HA, Smith MF (January 1993). "Basis of norgestomet action as a progestogen in cattle". Domestic Animal Endocrinology. 10 (1): 21–30. doi:10.1016/0739-7240(93)90005-v. PMID 8467644.
  4. ^ a b c d "Norgestomet". Drugs.com. Archived from the original on 28 February 2018.
  5. ^ Gordon U (22 October 2013). "Artificial Control O Oestrus and Ovulation". Controlled Breeding in Farm Animals. Elsevier. pp. 40–. ISBN 978-1-4832-8569-6.
  6. ^ Houghton PL (1979). "Effect of time of insemination and calf removal after estrus synchronization in beef cattle".