Integrin beta 3

ITGB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4O02, 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1S4X, 1TYE, 1U8C, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 5HDB, 4Z7Q, 4Z7O, 4Z7N
Identifiers
Aliases	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2
External IDs	OMIM: 173470; MGI: 96612; HomoloGene: 55444; GeneCards: ITGB3; OMA:ITGB3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,253,827 bp[1] End 47,313,743 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 67.84 cM Start 104,498,826 bp[2] End 104,561,302 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte thoracic aorta ascending aorta Descending thoracic aorta right lobe of thyroid gland left lobe of thyroid gland tendon of biceps brachii popliteal artery tibial arteries right coronary artery Top expressed in ascending aorta aortic valve decidua blood endothelial cell of lymphatic vessel granulocyte superior surface of tongue femur body of femur zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor receptor 2 binding fibronectin binding virus receptor activity extracellular matrix binding protein disulfide isomerase activity protease binding platelet-derived growth factor receptor binding protein binding identical protein binding enzyme binding cell adhesion molecule binding neuregulin binding coreceptor activity fibroblast growth factor binding insulin-like growth factor I binding C-X3-C chemokine binding integrin binding fibrinogen binding Cellular component integral component of membrane cell projection alphav-beta3 integrin-vitronectin complex membrane focal adhesion melanosome receptor complex plasma membrane integral component of plasma membrane ruffle membrane cell surface cell junction integrin complex platelet alpha granule membrane integrin alphav-beta3 complex extracellular exosome lamellipodium membrane nucleus microvillus membrane filopodium membrane alphav-beta3 integrin-IGF-1-IGF1R complex alphav-beta3 integrin-PKCalpha complex alphav-beta3 integrin-HMGB1 complex glutamatergic synapse synapse Biological process negative regulation of lipoprotein metabolic process apolipoprotein A-I-mediated signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein phosphorylation regulation of cell migration negative chemotaxis positive regulation of endothelial cell proliferation tube development heterotypic cell-cell adhesion angiogenesis involved in wound healing wound healing platelet degranulation blood coagulation extracellular matrix organization smooth muscle cell migration positive regulation of endothelial cell migration cell growth cell-substrate adhesion vascular endothelial growth factor receptor signaling pathway cell adhesion positive regulation of peptidyl-tyrosine phosphorylation mesodermal cell differentiation cell-substrate junction assembly integrin-mediated signaling pathway negative regulation of lipid storage substrate adhesion-dependent cell spreading negative regulation of lipid transport cell-matrix adhesion viral process regulation of bone resorption platelet aggregation cell migration negative regulation of macrophage derived foam cell differentiation activation of protein kinase activity leukocyte migration cell adhesion mediated by integrin platelet activation apoptotic cell clearance regulation of postsynaptic neurotransmitter receptor internalization regulation of protein localization regulation of serotonin uptake Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3690 16416 Ensembl ENSG00000259207 ENSMUSG00000020689 UniProt P05106 O54890 RefSeq (mRNA) NM_000212 NM_016780 RefSeq (protein) NP_000203 NP_058060 Location (UCSC) Chr 17: 47.25 – 47.31 Mb Chr 11: 104.5 – 104.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.^[5] CD61 is a cluster of differentiation found on thrombocytes.^[6]

Structure and function

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.^[7]

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.^[8]

Interactions

CD61 has been shown to interact with PTK2,^[9][10] ITGB3BP,^[11][12] TLN1^[13][14] and CIB1.^[15]

See also

• Glycoprotein IIb/IIIa

References

1. GRCh38: Ensembl release 89: ENSG00000259207 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020689 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, et al. (June 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". The Journal of Clinical Investigation. 81 (6): 1993–1998. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
6. Heemskerk JW, Mattheij NJ, Cosemans JM (January 2013). "Platelet-based coagulation: different populations, different functions" (PDF). Journal of Thrombosis and Haemostasis. 11 (1): 2–16. doi:10.1111/jth.12045. PMID 23106920. S2CID 206157070.
7. "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".
8. May KE, Villar J, Kirtley S, Kennedy SH, Becker CM (2011). "Endometrial alterations in endometriosis: a systematic review of putative biomarkers". Human Reproduction Update. 17 (5): 637–653. doi:10.1093/humupd/dmr013. PMID 21672902.
9. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, et al. (April 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". The Journal of Cell Biology. 157 (1): 149–160. doi:10.1083/jcb.200109079. PMC 2173263. PMID 11927607.
10. Chung J, Gao AG, Frazier WA (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". The Journal of Biological Chemistry. 272 (23): 14740–14746. doi:10.1074/jbc.272.23.14740. PMID 9169439.
11. Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thrombosis Research. 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. PMID 11864709.
12. Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, et al. (November 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". The Journal of Cell Biology. 131 (3): 807–816. doi:10.1083/jcb.131.3.807. PMC 2120613. PMID 7593198.
13. Patil S, Jedsadayanmata A, Wencel-Drake JD, Wang W, Knezevic I, Lam SC (October 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". The Journal of Biological Chemistry. 274 (40): 28575–28583. doi:10.1074/jbc.274.40.28575. PMID 10497223.
14. Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, et al. (June 2002). "The phosphotyrosine binding-like domain of talin activates integrins". The Journal of Biological Chemistry. 277 (24): 21749–21758. doi:10.1074/jbc.M111996200. PMID 11932255.
15. Naik UP, Patel PM, Parise LV (February 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". The Journal of Biological Chemistry. 272 (8): 4651–4654. doi:10.1074/jbc.272.8.4651. PMID 9030514.

Further reading

• Bray PF (October 1994). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thrombosis and Haemostasis. 72 (4): 492–502. PMID 7878622.
• Bennett JS (2001). "Platelet-fibrinogen interactions". Annals of the New York Academy of Sciences. 936 (1): 340–354. Bibcode:2001NYASA.936..340B. doi:10.1111/j.1749-6632.2001.tb03521.x. PMID 11460491. S2CID 25431334.
• Sajid M, Stouffer GA (February 2002). "The role of alpha(v)beta3 integrins in vascular healing". Thrombosis and Haemostasis. 87 (2): 187–193. doi:10.1055/s-0037-1612971. PMID 11858476.
• Quinn MJ, Byzova TV, Qin J, Topol EJ, Plow EF (June 2003). "Integrin alphaIIbbeta3 and its antagonism". Arteriosclerosis, Thrombosis, and Vascular Biology. 23 (6): 945–952. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (January 2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22. PMID 12690916.
• Smith FB, Connor JM, Lee AJ, Cooke A, Lowe GD, Rumley A, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thrombosis Research. 112 (4): 209–216. doi:10.1016/j.thromres.2003.11.010. PMID 14987913.
• Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Current Pharmaceutical Design. 10 (14): 1567–1576. doi:10.2174/1381612043384682. PMID 15134555.
• Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Current Medicinal Chemistry. 12 (1): 51–70. doi:10.2174/0929867053363522. PMID 15638730.
• Watson SP, Auger JM, McCarty OJ, Pearce AC (August 2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". Journal of Thrombosis and Haemostasis. 3 (8): 1752–1762. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042. S2CID 42666713.
• Bennett JS (December 2005). "Structure and function of the platelet integrin alphaIIbbeta3". The Journal of Clinical Investigation. 115 (12): 3363–3369. doi:10.1172/JCI26989. PMC 1297263. PMID 16322781.

External links

• CD61+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• ITGB3 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
• Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser.