Airtricity were announced as the new main sponsor for the League of Ireland on 26 February.[2][3] The prize fund for the season was set at €911,000.[4][5] The 2010 Premier Division featured 10 clubs. The regular season began on 5 March and concluded on 29 October. Each team played every other team four times, totalling 36 matches.[6] On the final day of the season, Shamrock Rovers won the title with a 2–2 draw away to Bray Wanderers.[7][8] Second placed Bohemians finished level on points with Rovers but lost out on goal difference.[9][10]
The eighth and ninth placed teams from the Premier Division, Galway United and Bray Wanderers, played off after the regular season was completed. The winner would retain a place in the 2011 Premier Division. The loser would play off against the winner of the 2010 First Division play off. The winner of this match would also gain a place in the 2010 Premier Division.