CCL23

CCL23
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1G91
Identifikatori
Aliasi	CCL23
Vanjski ID-jevi	OMIM: 602494 MGI: 98263 HomoloGene: 89167 GeneCards: CCL23
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17q12 Početak 36,013,056 bp[1] Kraj 36,017,972 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 C|11 50.85 cM Početak 83,478,708 bp[2] Kraj 83,483,913 bp[2]
Ontologija gena Molekularna funkcija • cytokine activity • heparin binding • chemokine activity • CCR1 chemokine receptor binding • CCR chemokine receptor binding Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • G protein-coupled receptor signaling pathway • monocyte chemotaxis • chemokine-mediated signaling pathway • cell-cell signaling • cellular response to tumor necrosis factor • cellular calcium ion homeostasis • neutrophil chemotaxis • Hemotaksija • negative regulation of C-C chemokine binding • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • cellular response to interleukin-1 • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • lymphocyte chemotaxis • GO:0072468 Transdukcija signala • negative regulation of cell population proliferation • inflammatory response • regulation of signaling receptor activity • eosinophil chemotaxis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6368	20305
Ensembl	ENSG00000276114 ENSG00000274736	ENSMUSG00000018927
UniProt	P55773	P27784
RefSeq (mRNK)	NM_005064 NM_145898	NM_009139
RefSeq (bjelančevina)	NP_005055 NP_665905	NP_033165
Lokacija (UCSC)	Chr 17: 36.01 – 36.02 Mb	Chr 11: 83.48 – 83.48 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Hemokinski (C-C motivni) ligand 23
Identifikatori
Simbol	CCL23
Alt. simboli	SCYA23, Ckb-8, MPIF-1, MIP-3, CKb8
NCBI gen	6368
HGNC	10622
OMIM	602494
PDB	1G91
RefSeq	NM_005064
UniProt	P55773
Ostali podaci
Lokus	Hrom. 17 q11.2
Pretraga za Strukture Swiss-model Domene InterPro

Hemokinski (C-C motivni) ligand 23 (CCL23) je mali citokin koji pripadaju porodici CC hemokina, poznatoj i kao makrofagni upalni protein 3 (MIP-3) i mijeloidni progenitorski inhibitorni faktor 1 (MPIF-1). CCL23 se pretežno eksprimira u tkivima pluća i jetre , ali također i u koštanoj srži i posteljicama.^[5] Eksprimira se i u nekim ćelijskim linijama mijeloidnog porijekla. CCL23 je vrlo hemotaktičan za mirovanje T-ćelija i monocita i blago hemotaktičan za neutrofile. Također se pripisuje inhibitornoj aktivnosti na prekursorima hematopoetskih ćelija.^[5] Gen za CCL23 nalazi se na ljudskom hromosomu 17 u lokusu koji sadrži nekoliko drugih CC-hemokina. CCL23 je ligand za hemokinski receptor CCR1.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 120 aminokiselina, a molekulska težina 13.411 Da^[7].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin

L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MKVSVAALSC		LMLVTALGSQ		ARVTKDAETE		FMMSKLPLEN		PVLLDRFHAT
SADCCISYTP		RSIPCSLLES		YFETNSECSK		PGVIFLTKKG		RRFCANPSDK
QVQVCVRMLK		LDTRIKTRKN

Reference

1. ENSG00000274736 GRCh38: Ensembl release 89: ENSG00000276114, ENSG00000274736 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018927 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Patel et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185: 1163-1172, 1997.
6. Berahovich et al. Proteolytic Activation of Alternative CCR1 Ligands in Inflammation. J. Immunol. 174:7341-7351, 2005.
7. "UniProt, P55773". Pristupljeno 26. 6. 2021.

Vanjski linkovi