CCL27

CCL27
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2KUM
Identifikatori
Aliasi	CCL27
Vanjski ID-jevi	OMIM: 604833 MGI: 1891389 HomoloGene: 104838 GeneCards: CCL27
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek)[1] Bend 9p13.3 Početak 34,661,880 bp[1] Kraj 34,664,048 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4 A5|4 Početak 42,655,251 bp[2] Kraj 42,656,005 bp[2]
Ontologija gena Molekularna funkcija • chemokine activity • cytokine activity • CCR3 chemokine receptor binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • Hemotaksija • cell-cell signaling • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • cell chemotaxis • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • positive regulation of T cell chemotaxis • positive regulation of mononuclear cell migration • positive regulation of actin cytoskeleton reorganization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10850	100040048
Ensembl	ENSG00000213927	ENSMUSG00000096826
UniProt	Q9Y4X3	Q9Z1X0
RefSeq (mRNK)	NM_006664	NM_001199959 NM_001199960 NM_001199961
RefSeq (bjelančevina)	NP_006655	NP_001041644 NP_001157516 NP_001157517 NP_001333994 NP_001348175 NP_035466
Lokacija (UCSC)	Chr 9: 34.66 – 34.66 Mb	Chr 4: 42.66 – 42.66 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Hemokinski (C-C motivni) ligand 27
Identifikatori
Simbol	CCL27
Alt. simboli	SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
NCBI gen	10850
HGNC	10626
OMIM	604833
RefSeq	NM_006664
UniProt	Q9Y4X3
Ostali podaci
Lokus	Hrom. 9 q13
Pretraga za Strukture Swiss-model Domene InterPro

C-C motivni hemokinski ligand 27 jest protein koji je kod ljudi kodiran genom CCL27.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 112 aminokiselina, а molekulska težina 12.618 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MKGPPTFCSL		LLLSLLLSPD		PTAAFLLPPS		TACCTQLYRK		PLSDKLLRKV
IQVELQEADG		DCHLQAFVLH		LAQRSICIHP		QNPSLSQWFE		HQERKLHGTL
PKLNFGMLRK		MG

Funkcija

Ovaj gen je jedan od nekoliko gena CC citokina grupiranih na p-kraku hromosoma 9. Citokini su porodica izlučenih proteina uključenih u imunoregulacijske i upalne procese. CC citokini su proteini koje karakteriziraju dva susjedna cisteina. Protein kodiran ovim genom je hemotaksijski za kožne povezane memorijske T-limfocite. CCL27 je povezan sa preusmjeravanjem memorije T-limfocita na kožu i ima ulogu u upalama kože posredovanim T-ćelijama.^[7][8]

CCL27 se eksprimira u brojnim tkivima, uključujući gonade, timus, placentu i kožu. Izaziva svoje hemotaksijske efekte vezanjem za receptor za hemokine CCR10.^[9] Gen za CCL27 kod ljudi nalazi se na hromosomu 9.^[10] Studije sličnog mišjeg proteina ukazuju da ove interakcije protein-receptor imaju ključnu ulogu u T-ćelijama posredovanoj upali kože (prema RefSeq, Sep 2014).

Reference

1. GRCh38: Ensembl release 89: ENSG00000213927 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000096826 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: C-C motif chemokine ligand 27". Pristupljeno 23. 3. 2018.
6. "UniProt, Q9Y4X3". Pristupljeno 7. 9. 2021.
7. Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
8. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, et al. (februar 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nature Medicine. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. S2CID 35433583.
9. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, et al. (april 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". Journal of Immunology. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
10. Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, et al. (novembar 1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus". FEBS Letters. 460 (3): 544–8. doi:10.1016/s0014-5793(99)01406-4. PMID 10556532. S2CID 39019419.

Dopunska literatura

• Mackay CR (februar 2002). "New avenues for anti-inflammatory therapy". Nature Medicine. 8 (2): 117–8. doi:10.1038/nm0202-117. PMID 11821893. S2CID 26588760.
• Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, et al. (mart 2003). "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris". The Journal of Allergy and Clinical Immunology. 111 (3): 592–7. doi:10.1067/mai.2003.114. PMID 12642842.
• Hijnen D, De Bruin-Weller M, Oosting B, Lebre C, De Jong E, Bruijnzeel-Koomen C, Knol E (februar 2004). "Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis". The Journal of Allergy and Clinical Immunology. 113 (2): 334–40. doi:10.1016/j.jaci.2003.12.007. PMID 14767451.
• Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M (septembar 2004). "TARC augments TNF-alpha-induced CTACK production in keratinocytes". Experimental Dermatology. 13 (9): 551–7. doi:10.1111/j.0906-6705.2004.00202.x. PMID 15335355. S2CID 84940084.
• Hirata T, Furukawa Y, Yang BG, Hieshima K, Fukuda M, Kannagi R, et al. (decembar 2004). "Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus". The Journal of Biological Chemistry. 279 (50): 51775–82. doi:10.1074/jbc.M409868200. PMID 15466853.
• Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L (januar 2005). "Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB". Cytokine. 29 (2): 49–55. doi:10.1016/j.cyto.2004.09.008. PMID 15598438.
• Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, et al. (februar 2005). "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure". Experimental Dermatology. 14 (2): 109–16. doi:10.1111/j.0906-6705.2005.00226.x. PMID 15679580. S2CID 8770112.
• Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, et al. (februar 2006). "CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27". Experimental Dermatology. 15 (2): 95–100. doi:10.1111/j.1600-0625.2005.00390.x. PMID 16433680. S2CID 31590665.

Vanjski linkovi