Exaprolol

Exaprolol
Names
IUPAC name
1-(2-Cyclohexylphenoxy)-3-(propan-2-ylamino)propan-2-ol
Other names
Esprolol
Identifiers
3D model (JSmol)
ChemSpider
KEGG
UNII
  • InChI=1S/C18H29NO2/c1-14(2)19-12-16(20)13-21-18-11-7-6-10-17(18)15-8-4-3-5-9-15/h6-7,10-11,14-16,19-20H,3-5,8-9,12-13H2,1-2H3
    Key: ABXHHEZNIJUQFM-UHFFFAOYSA-N
  • CC(C)NCC(COC1=CC=CC=C1C2CCCCC2)O
Properties
C18H29NO2
Molar mass 291.435 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Exaprolol is a beta-adrenoceptor antagonist.[1]

Synthesis

Exaprolol synthesis[2]

References

  1. ^ Van Waarde, A; Doorduin, J; De Jong, JR; Dierckx, RA; Elsinga, PH (2008). "Synthesis and preliminary evaluation of (S)-11C-exaprolol, a novel beta-adrenoceptor ligand for PET". Neurochemistry International. 52 (4–5): 729–33. doi:10.1016/j.neuint.2007.09.009. PMID 17961850.
  2. ^ Carissimi, M; Gentili, P; Grumelli, E; Milla, E; Picciola, G; Ravenna, F (1976). "Basic ethers of cyclohexylphenols with beta-blocking activity: Synthesis and pharmacological study of exaprolol". Arzneimittel-Forschung. 26 (4): 506–16. PMID 8056.


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