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Levobetaxolol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	topical (ophthalmic)
ATC code	none;
Pharmacokinetic data
Elimination half-life	20 hours
Identifiers
	IUPAC name (S)-1-[p-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)-2-propanol hydrochloride;
CAS Number	93221-48-8 ;
PubChem CID	60657;
IUPHAR/BPS	8035;
ChemSpider	54669 ;
UNII	75O9XHA4TU;
ChEBI	CHEBI:59254 ;
ChEMBL	ChEMBL1201274 ;
CompTox Dashboard (EPA)	DTXSID30239341 ;
Chemical and physical data
Formula	C18H29NO3
Molar mass	307.434 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(CCc1ccc(OC[C@@H](O)CNC(C)C)cc1)CC2CC2;
	InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m0/s1 ; Key:NWIUTZDMDHAVTP-KRWDZBQOSA-N ;
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Levobetaxolol is a drug used to lower the pressure in the eye in treating conditions such as glaucoma. It is marketed as a 0.25 or 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon. Levobetaxolol is a beta-adrenergic receptor inhibitor (beta blocker).

Indications

It is indicated for intraocular pressure reduction in patients with open-angle glaucoma or ocular hypertension.^[1]

Effect

Levobetaxolol inhibits the beta-1-adrenergic receptor. When applied topically, it reduces intra-ocular pressure (IOP) by 16-23% depending on time of day and the individual. It also has neuroprotective effects.^[1] Levobetaxolol has fewer cardiovascular side effects than other beta blockers.

Contraindications and side effects

Levobetaxolol should not be used by people who have sinus bradycardia, atrioventricular block, cardiogenic shock, or overt cardiac failure. The drug has been associated with bradycardia and hypertension.^{[citation needed]}

History

Levobetaxolol was developed in the 1980s.^[1] It was FDA approved in 2000.^[2]

References

^ ^a ^b ^c Quaranta L, Turano R, Pizzolante T (June 2007). "Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension". Clinical Ophthalmology. 1 (2): 93–7. PMC 2704505. PMID 19668496.
^ "Betaxon New FDA Drug Approval | CenterWatch". www.centerwatch.com. Retrieved 11 April 2019.

[levo-1] Quaranta L, Turano R, Pizzolante T (June 2007). "Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension". Clinical Ophthalmology. 1 (2): 93–7. PMC 2704505. PMID 19668496.

[2] "Betaxon New FDA Drug Approval | CenterWatch". www.centerwatch.com. Retrieved 11 April 2019.

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