She studied law in the Centre for Human Rights at Pretoria University in South Africa.[4] Before joining OSIWA, she previously worked for Save the Children and USAID.[5] In March 2020, she was one of the three Africans appointed to sit on the Facebook Oversight Board.[6] In July 2023, following a recommendation from the oversight board to deplatform Cambodian head of state Hun Sen, the government of Cambodia listed Asare-Kyei as one of 22 people connected with Meta who were banned from entering the country.[7]