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纳他霉素

纳他霉素
臨床資料
商品名英语Drug nomenclatureNatacyn, others
AHFS/Drugs.comMonograph
给药途径眼藥水[1]
ATC碼
识别信息
  • (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(3-amino-3,6-dideoxy-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
CAS号7681-93-8
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
E编码E235 (preservatives) 編輯維基數據鏈接
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.028.803 編輯維基數據鏈接
化学信息
化学式C33H47NO13
摩尔质量665.73 g·mol−1
3D模型(JSmol英语JSmol
密度1.35 g/ml g/cm3
熔点Darkens at ±200 °C with vigorous decomposition at 280-300 °C
水溶性0.39 mg/ml mg/mL (20 °C)
  • OC(=O)[C@@H]3[C@@H](O)C[C@@]2(O)C[C@@H](O)C[C@H]4O[C@@H]4/C=C/C(=O)O[C@H](C)C\C=C\C=C\C=C\C=C\[C@H](O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O)C[C@@H]3O2
  • InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
     checkY
  • Key:NCXMLFZGDNKEPB-FFPOYIOWSA-N

纳他霉素纳他链霉菌Streptomyces natalensis)在发酵过程中产生的天然多烯大环内酯类化合物[2]。因其对霉菌酵母有较强的抑制作用, 而常被用作食品防腐剂[2],广泛用于肉类乳制品的防腐和果蔬的保鲜[3]

纳他霉素可与真菌细胞膜上的甾醇类物质结合,引起细胞死亡[4]。纳他霉素还能抑制灰葡萄孢Botrytis cinerea)、扩展青霉Penicillium expansum)和尖孢炭疽菌Colletotrichum acutatum)的孢子萌发和菌丝生长[3]

参考文献

  1. ^ Natamycin. The American Society of Health-System Pharmacists. [8 December 2017]. (原始内容存档于2017-12-10). 
  2. ^ 2.0 2.1 Hondrodimou, O.; Kourkoutas, Y.; Panagou, E.Z. Efficacy of natamycin to control fungal growth in natural black olive fermentation. Food Microbiology. 2011-05, 28 (3): 621–627. PMID 21356474. doi:10.1016/j.fm.2010.11.015. 
  3. ^ 3.0 3.1 刘佳怡, 王嘉欣; Jiayi Liu, Jiaxin Wang. 纳他霉素对芒果采后胶孢炭疽菌的抑菌效果及机理. 植物学报. 2019-07-10, 54 (4): 455. doi:10.11983/CBB19044. 
  4. ^ Aparicio, Jesús F.; Barreales, Eva G.; Payero, Tamara D.; Vicente, Cláudia M.; de Pedro, Antonio; Santos-Aberturas, Javier. Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation. Applied Microbiology and Biotechnology. 2016-01, 100 (1): 61–78. PMID 26512010. doi:10.1007/s00253-015-7077-0. 

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