Kaspaza-9

Kaspaza-9
Identifikatori
EC broj	3.4.22.62
CAS broj	180189-96-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Kaspaza-9 (EC 3.4.22.62, CASP-9, ICE-slična apoptotička proteaza 6, ICE-LAP6, apoptotička proteaza Mch-6, apoptotičko proteazni aktivirajući faktor 3, APAF-3) je enzim.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji i preferentno je His u poziciji P2. Preferentno dolazi do razlaganja sekvence Leu-Gly-His-Asp-Xaa

Kaspaza-9 je efektor/izvršilac kaspaze, kao što su i kaspaza-2 (EC 3.4.22.55), kaspaza-8 (EC 3.4.22.61) i kaspaza-10 (EC 3.4.22.63).

Reference

1. Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820. 
2. Yin, Q., Park, H.H., Chung, J.Y., Lin, S.C., Lo, Y.C., da Graca, L.S., Jiang, X. and Wu, H. (2006). „Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine”. Mol. Cell. 22: 259-268. PMID 16630893. 
3. Boatright, K.M., Renatus, M., Scott, F.L., Sperandio, S., Shin, H., Pedersen, I.M., Ricci, J.E., Edris, W.A., Sutherlin, D.P., Green, D.R. and Salvesen, G.S. (2003). „A unified model for apical caspase activation”. Mol. Cell. 11: 529-541. PMID 12620239. 
4. Salvesen, G.S. and Boatright, K.M. (2004). „Caspase-9”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1296-1298. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 
• Salvesen, G.S. and Boatright, K.M. (2004). „Caspase-9”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1296-1298. 

Spoljašnje veze

• MeSH Caspase-9