Kaspaza-11

Kaspaza-11
Identifikatori
EC broj	3.4.22.64
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Kaspaza-11 (EC 3.4.22.64, CASP-11) je enzim.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence (Ile/Leu/Val/Phe)-Gly-His-Asp-

Ovaj murinski enzim je deo familije inflamatornih kaspaza, u koji se takođe ubrajaju kaspaza-1 (EC 3.4.22.36), kaspaza-4 (EC 3.4.22.57) i kaspaza-5 (EC 3.4.22.58) kod ljudi i kaspaza-12, kaspaza-13 i kaspaza-14 kod miševa.

Reference

1. Kang, S.J., Wang, S., Hara, H., Peterson, E.P., Namura, S., Amin-Hanjani, S., Huang, Z., Srinivasan, A., Tomaselli, K.J., Thornberry, N.A., Moskowitz, M.A. and Yuan, J. (2000). „Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions”. J. Cell. Biol. 149: 613-622. PMID 10791975. 
2. Hur, J., Kim, S.Y., Kim, H., Cha, S., Lee, M.S. and Suk, K. (2001). „Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway”. FEBS Lett. 507: 157-162. PMID 11684090. 
3. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E. and Yuan, J. (1998). „Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE”. Cell 92: 501-509. PMID 9491891. 
4. Endo, M., Mori, M., Akira, S. and Gotoh, T. (2006). „C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation”. J. Immunol. 176: 6245-6253. PMID 16670335. 
5. Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH Caspase-11