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Minichromosome maintenance complex component 5
Identifikatori
Simboli	MCM5; CDC46; P1-CDC46
Vanjski ID	OMIM: 602696 MGI: 103197 HomoloGene: 4904 GeneCards: MCM5 Gene
EC broj	3.6.4.12
Ontologija gena
Molekulska funkcija	• DNK vezivanje; • aktivnost DNK helikaze; • proteinsko vezivanje;
Ćelijska komponenta	• nukleus; • nukleoplazma; • nukleolus;
Biološki proces	• G1/S tranzicija mitotičkog ćelijskog ciklusa; • mitotički ćelijski ciklus; • DNK replikacija;
Pregled RNK izražavanja
	podaci
Ortolozi

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Faktor licenciranja DNK replikacije MCM5 je protein koji je kod ljudi kodiran MCM5 genom.^[1]^[2]^[3]

Protein kodiran ovim genom je strukturno veoma slian CDC46 proteinu iz S. cerevisiae, proteinu koji učestvuje u inicijaciji DNK replikacije. Ovaj protein je član MCM familije proteina koji vezuju hromatin. On može da formira interakcije sa najmanje dva druga člana ove familije. Ovaj protein je u većoj meri izražen tokom tranzicije iz G0 faze u G1/S fazu ćelijskog ciklusa, i smatra se da aktivno učestvuje u regulaciji ćelijskog ciklusa.^[3]

Povezano

Održavanje minihromozoma

Interakcije

MCM5 formira interakcije sa ORC2L,^[4] MCM7,^[4]^[5]^[6] STAT1,^[6]^[7] MCM2,^[4]^[6] CDC7,^[4] MCM3^[4]^[6] i ORC6L.^[4]

Reference

↑ Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). „Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5”. Cytogenet Cell Genet 73 (4): 317–21. DOI:10.1159/000134366. PMID 8751386.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). „The DNA sequence of human chromosome 22”. Nature 402 (6761): 489–95. DOI:10.1038/990031. PMID 10591208.
↑ ^3,0 ^3,1 „Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)”.
↑ ^4,0 ^4,1 ^4,2 ^4,3 ^4,4 ^4,5 Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. (England) 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
↑ Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (Apr 1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. DOI:10.1074/jbc.272.16.10928. ISSN 0021-9258. PMID 9099751.
↑ ^6,0 ^6,1 ^6,2 ^6,3 DaFonseca, C J; Shu F; Zhang J J (Mar 2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. DOI:10.1073/pnas.061487598. ISSN 0027-8424. PMC 30602. PMID 11248027.
↑ Zhang, J J; Zhao Y; Chait B T; Lathem W W; Ritzi M; Knippers R; Darnell J E (Dec 1998). „Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation”. EMBO J. (ENGLAND) 17 (23): 6963–71. DOI:10.1093/emboj/17.23.6963. ISSN 0261-4189. PMC 1171044. PMID 9843502.

Literatura

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